Electron cryo-microscopy, cryoEM, is rapidly replacing X-ray crystallography as the preferred method in structural biology for determining the structures of biological molecules. The rise of cryoEM can be traced to the introduction of higher detective quantum efficiency, DQE, CMOS based direct electron detectors. The resulting improved signal to noise in images of radiation sensitive samples...
Positron emission tomography is a powerful tool in nuclear medicine for diagnosing cancers and Alzheimer’s disease in early stages. We develop a sensor head for a Time-of-flight PET scanner using plastic scintillators which have a very fast timing property. Since the cross section of the photoelectric absorption in plastic scintillators is extremely small at 511 keV, we use Compton scattering...
The TT-PET project aims at developing a compact Time-of-flight PET scanner with 30ps time resolution, capable of withstanding high magnetic fields and allowing for integration in a traditional MRI scanner, providing complimentary real-time PET images. The very high timing resolution of the TT-PET scanner is achieved thanks to a new generation of Silicon-Germanium (Si-Ge) amplifiers, which are...
Positron range effects in positron emission tomography (PET) studies have a negative impact in both spatial resolution and activity concentration quantification, particularly when high energy positron emitters travel in low density tissues. Several methods have been proposed to recover spatial resolution in PET with the aim of improving image quality. In this work, we propose a regularized...
The optimization and characterization of a large area detector module, aimed at constructing a positron emission mammogram prototype, is presented. The device features a SensL ArrayC-60035-64P-PCB solid state detector (8x8 array of tileable SiPM by SensL, 7.2 mm pitch) covering a total area of 57.4×57.4 mm2. The array was tested using 10 mm thick, LYSO pixelated crystal arrays of different...
