Seminario: La Física del Cáncer

Contribution List

2. "Defining the role of stem and progenitor cells during tumour initiation"

Adriana Sanchez Danes

16/05/2017, 09:00

Many cancers arise from tissues maintained by stem and progenitor cells that ultimately give rise to non-dividing terminally differentiated cells. However, little is known about the contribution of stem cells and committed progenitors to cancer initiation.
In this study we assess the role of stem cells and progenitor cells in cancer initiation. Using skin epidermis as a model, we studied the...

1. "Stochastic fate choices during cancer initiation"

Edouard Hannezo

16/05/2017, 09:30

Abstract: "The changes in cell dynamics after oncogenic mutation that lead to the development of tumours are currently unknown. Here, using skin epidermis as a model, we assessed the effect of oncogenic hedgehog signalling in distinct cell populations and their capacity to induce basal cell carcinoma, the most frequent cancer in humans. We found that only stem cells, and not progenitors,...

3. "Mechanical guidance of collective cell migration and invasion"

Xavier Trepat

16/05/2017, 10:00

A broad range of biological processes such as morphogenesis, tissue regeneration, and cancer invasion depend on the collective migration of epithelial cells. Guidance of collective cell migration is commonly attributed to soluble or immobilized chemical gradients. I will present novel mechanisms of collective cellular guidance that are physical in origin rather than chemical. Firstly, I will...

4. "Physics-like modeling of brain tumors: Solitons, surface-driven phenomena, scaling laws and more."

Víctor M. Pérez-García

16/05/2017, 10:50

In this talk I will describe how mathematical modeling of brain tumors inspired by physical phenomena can shed light on the dynamics of gliomas. I will describe novel therapies, imaging based biomarkers, counter-intuitive alternative treatment schedules, surface-driven phenomena and scaling laws. All of this phenomena will be discussed on the light of using mathematical (physics-like) modeling...

5. "Bioelectricity and Intercellular Communication in Model Multicellular Ensembles"

Salvador Mafe

16/05/2017, 11:20

Cancer research tends to focus on genes and biochemistry. However, bioelectricity and intercellular electrical coupling could also be significant. Experiments with model animals and cell culture assays suggest the instructive role of spatio-temporal maps of cell membrane potentials. These potentials regulate and are regulated by the ion channel proteins that transport signaling molecules, thus...

7. "Dynamics and Physics of Cancer: Tumor and Immune Cell Interactions"

Jesús Seoane

16/05/2017, 11:50

In this plenary talk we present our work in Dynamics and Physics of Cancer [1,2,3,4]. In particular, our study uses in silico experiments and mathematical analyses to characterize the transient and asymptotic dynamics of the cell-mediated immune response to tumor growth. An hybrid probabilistic cellular automaton model describing the spatio-temporal evolution of tumor growth and its...

6. "The dose-dense principle in cancer chemotherapy"

Alvaro G. López

16/05/2017, 12:30

Chemotherapy is a class of cancer treatment that uses drugs to kill cancer cells. A typical chemotherapeutic protocol consists of several drugs delivered in cycles of three weeks. We present mathematical analyses demonstrating the existence of a minimum time between cycles of chemotherapy for a protocol to be effective. A mathematical equation is derived, which relates such a minimum time with...

8. Deep changes in radiology

Emilio Soria

16/05/2017, 13:00

This talk explains how deep technologies of automatic learning will affect radiology. Deep learning algorithms, techniques of deep reinforcement learning and their possible application to radiology are discussed.

Short CV;
Emilio Soria Olivas holds a degree in Physics (1992), an extraordinary award and a PhD in electronic engineering (1997). He is currently a University professor in the...