Speaker
Dr
Niels Harlaar
(Institute for Medical and Biological Imaging, Technical University Munich and Helmholtz Center and Department of Surgery and BioOptical Imaging Center Groningen, University Medical Center Groningen)
Description
We have developed an advanced multi-spectral fluorescence real-time imaging platform for assessing in positive surgical margins, loco-regional metastases and overall physiological and molecular biomarkers intra-operatively. The approach utilizes fluorochromes with targeting specificity, advanced optical imaging instrumentation and algorithms that yield quantitative and sensitive fluorescence imaging in tissues. This technique ties well with surgical practices and offers high potential for practical dissemination. In this talk, we will present the system and overall strategy, results from animal experiments by using targeted probes in an animal breast cancer model, the first results in patients with a sentinel-lymph-node detection in breast conserving surgery together with future targeted fluorescent probes.
Author
Dr
Niels Harlaar
(Institute for Medical and Biological Imaging, Technical University Munich and Helmholtz Center and Department of Surgery and BioOptical Imaging Center Groningen, University Medical Center Groningen)
Co-authors
Dr
Gooitzen Van Dam
(Department of Surgery and BioOptical Imaging Center Groningen, University Medical Center Groningen)
Dr
Vasilis Ntziachristos
(Institute for Medical and Biological Imaging, Technical University Munich and Helmholtz Center)
