Speaker
Description
Background / Aims: In the 1970’s and 80’s major accelerator facilities operating at 100 MeV and higher were developed and installed in many of the national labs and used for production of radionuclides at much higher energies than can be achieved on the small compact machines. These high energy accelerators play a critical role in supplying radionuclides such as Sr-82 used in Sr-82/Rb-82 generators for cardiac imaging and Ge-68 used in Ge-68/Ga-68 generators for imaging to quantitate receptor imaging for targeted therapy applications. They continue to be upgraded to increase production yields by installing beam rastering systems that have allowed higher intensities and thus higher production yields. Demand for isotopes that can be produced by these systems have also increased. Linear accelerators such as the one at Brookhaven National Laboratory when operating at maximum proton energy of 200 MeV can have simultaneous production of several medically relevant isotopes. Among those are Ac-225 (T1/2=10.0 d), Cu-67 (T1/2=64.83 h), Se-72/As-72 (T1/2=26 h), Sr-82/Rb-82 (T1/2=1.26 min) and Ti-44/Sc-44 (T1/2=3.97 h). Production of these novel radionuclides and recent enhancements will be presented.
Cathy S. Cutler* , Dmitri Medvedev, Leonard Mausner, Vanessa Sanders, Lisa Muench
Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY, United States
