Speaker
Dr
Yolanda Prezado
(European synchrotron Radiation Facility)
Description
Synchrotron radiation (SR) therapy is a promising alternative to treat brain tumors, whose management is limited due to the high morbidity of the surrouding healthy tissues. Several approaches are being explored by using SR. The European Synchrotron Radiation Facility (ESRF) in Grenoble (France) has devoted one of its lines to biomedical research, highly focused nowadays to the development of new radiotherapy techniques. At the ESRF three techniques are under development: Stereotactic Synchrotron Radiation Therapy (SSRT), Microbeam Radiation Therapy (MRT) and, more recently, Minibeam Radiation Therapy (MBRT). Those radiation therapy programs are progressing rapidly towards the clinical trials with promising results for the treatment of high grade brain tumors.
The preclinical studies on SSRT and MRT have shown promising results on healthy tissue sparing capability [1-4] and ablation of highly agressive tumor models [5-10], paving the way to clinical trials currently in preparation at the ESRF. With this aim, different dosimetric aspects from both theoretical and experimental points of view have been assessed in SSRT and MRT. In particular, the definition of safe irradiation protocols [11], the beam energy providing the best balance between tumor treatment and healthy tissue sparing in MRT [12] and MBRT [13], the special dosimetric considerations for small field dosimetry, etc will be described. In addition, for the clinical trials, the definition of appropiate dosimetry protocols for patients according to the well established European Medical Physics recommendations will be discussed.
Finally, the state of art of MBRT developments at the ESRF will be presented. MBRT is the most recently radiotherapy technique implemented at the ESRF [14]. The main advantag
Address
6 Jules Horowitz, Grenoble
Last Name
Prezado
Please submit a short bio (max 1500 characters)
I hold a PhD in experimental Nuclear Physics. The data was obtained through a series of experiments at CERN. I am a certified Medical Physicist. I have experience both in clinical assistance and research in Radiotherapy. I have worked during some years in Radiotherapy departments at two hospitals. I am currently working as a scientist and medical physicist at the Biomedical Beamline at the European Synchrotron Radiation Facility (ESRF) in France. My main research line is the development of new radiotherapy techniques by using synchrotron radiation. I work both in experimental and theoretical dosimetry for preclinical studies and to prepare the future clinical trials.
E-mail address
prezado@esrf.fr
First Name(s)
Yolanda
Institution
ESRF
Telephone
0033476882438
Author
Dr
Yolanda Prezado
(European synchrotron Radiation Facility)
Co-authors
Dr
Alberto Bravin
(European synchrotron Radiation Facility)
Mrs
Elke Brauer
(European synchrotron Radiation Facility)
Dr
Francois Estéve
(European synchrotron Radiation Facility, Université Joseph Fourier, INSERM U836, Centre Hospitalier Universitaire)
Ms
Giovanna Fois
(European synchrotron Radiation Facility, Universita Cagliari)
Dr
Helen Elleaume
(European synchrotron Radiation Facility, Université Joseph Fourier, INSERM U836, Centre Hospitalier Universitaire)
ID17 Biomedical Beamline ID17 Biomedical Beamline
(European synchrotron Radiation Facility)
Ms
Immaculada Martinez-Rovira
(European synchrotron Radiation Facility, Universitat Politecnica de Catalunya)
Dr
Jean Francois Adam
(European synchrotron Radiation Facility, Université Joseph Fourier, INSERM U836)
Ms
Magali Edouard
(European synchrotron Radiation Facility, Université Joseph Fourier, INSERM U836)
Mr
Mathias Vautrin
(Université Joseph Fourier, INSERM U836, DOSISOFT)
Mr
Michel Renier
(European synchrotron Radiation Facility)
Dr
Paul Berkvens
(European synchrotron Radiation Facility)
Ms
Sheeba Thengumpallil
(European synchrotron Radiation Facility, Universita Roma Tres)