Dr
Andrea Attili
(on behalf of the INFN-TPS collaboration)
Several technologies developed by the Italian institute of nuclear physics (INFN) for fundamental physics have been applied to medical imaging and particle therapy techniques. The partnership with leading industries has always been crucial for successful applications. Within this framework is the implementation of a Treatment Planning System (TPS) for hadrontherapy with C-ion beams, but not exclusively, in partnership with the IBA Group, with the contribution of the TPS manufacturer Elekta.
Several INFN research groups that have developed competencies in different scientific areas are cooperating to the task: experimental and phenomenological nuclear physics, Monte Carlo (MC) and techniques for numerical analysis, radiobiology and hardware development for monitoring purposes.
A TPS prototype is currently being studied. In order to achieve a fast plan optimization, the dose distribution is computed using look-up tables obtained from MC simulations. These are performed using Fluka and an implementation of the Local Effect Model (developed by the GSI Biophysics group).
Nuclear fragmentation experiments for C-ion are now performed at the INFN's Laboratori Nazionali del Sud (LNS) (30-80 MeV/n). Further experiments are scheduled at SIS (GSI) in the framework of the FIRST experiment (200-400 MeV/n), in collaboration with other European Institutes (GSI, ESA, CEA). Radiobiological experiments are underway at LNS and Laboratori Nazionali di Legnaro, on rodent and human cells (C-ion @ 8-80 MeV/n). Lighter ions (A=6-12) will also be used, to reproduce the effects of fragments (up to 20 MeV/u).
These experiments will provide reliable data for the validation of the simulations and for further improvements of the physical and radiobiological models to be used in the TPS.
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Andrea Attili Short Bio/CV:
Name: Andrea Attili.
Citizenship: Italian.
Born in Rome, 6 February 1972.
Marital status: Married.
2003 - Ph.D in Physics - Università degli studi "Roma Tre", Roma (Italy), "Study of the glass transition of a supercooled liquid mixture in bulk and confined phases". Sup.: Prof. M. Rovere and Dr. P. Gallo.
1998 - Graduated in Physics - Università degli studi "Roma Tre", Roma (Italy), "Study of the angular correlations between photo- and Auger-electron (APECS): an experiment on CU(111) using synchrotron radiation". Sup.: Prof. G. Stefani. Final grade: 110/110 cum laude.
2006-2009 Research activity in Medical Physics (development of a Treatment Planning Systems (TPS) for hadrontherapy) - Research position, INFN (Istituto Nazionale di Fisica Nucleare) - Sezione di Torino (Italy);
2005-2006 Research activity in Medical Physics (Monte Carlo simulations and radiobiological models for radiotherapy using ion beams) - Università degli Studi di Torino - Torino (Italy).
2004-2005 Research activity in Bioinformatics ("machine learning" automatic techniques for the prediction of the quality of proteins structural models) - Department of Biochemical Sciences, Università "La Sapienza" - Roma (Italy).
2000-2003 Research activity for the Ph.D (Modeling and simulation of supercooled liquids and of the glass transition) - Ph.D. grant, Università degli Studi "Roma Tre" - Roma (Italy).
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Via P. Giuria 1 - 10125 Torino - Italy
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Dr
Andrea Attili
(on behalf of the INFN-TPS collaboration)
