Dr
Peter Dendooven
(KVI, University of Groningen)
Positron emission tomography (PET) detectors based on a monolithic scintillation crystal coupled to a photosensor array can maximize scanner sensitivity and allow excellent intrinsic spatial resolution as well as depth-of-interaction (DOI) correction. Investigating the suitability of such detectors for time-of-flight (TOF) PET, we are focusing on the promising combination of fast and bright LaBr3 and LYSO scintillation crystals with silicon photomultiplier (SiPM) light sensors that provide low noise, high gain and small transit-time jitter.
In order to correct for the time walk as function of the 3D annihilation photon interaction location in the crystal, a maximum likelihood estimation algorithm to determine this location was developed. It was applied to a 20×20×12 mm3 LYSO:Ce crystal coupled to a fast 4×4 multianode photomultiplier (Hamamatsu H8711-03) and a bare 18.2×16×10 mm3 LaBr3:Ce(5%) crystal coupled to a Hamamatsu S11064-050P(X) 4×4 SiPM array. Throughout the LYSO crystal, the time walk spans a range of ~100 ps. Time walk calibration allows an event-by-event correction, resulting in an almost complete time walk cancellation. For the LaBr3 detector, time walk vs. DOI spanned only ~15 ps. For 511 keV photons, a single detector timing resolution for the LYSO and LaBr3 detectors of 305 ps and 225 ps FWHM, respectively, was achieved.
The intrinsic timing resolution of bare LaBr3:Ce(5%) crystals coupled to SiPMs was studied using small (3×3×5 mm3) crystals coupled to single Hamamatsu MPPC S10362-33-050C SiPMs. For 511 keV photon pairs, a coincidence resolving time (CRT) of 101 ps FWHM was obtained.
The setup and analysis of the experiments will be presented and favourable conclusions for TOF-PET using sensor arrays on monolithic crystals will be drawn.
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KVI, University of Groningen
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Zernikelaan 25, 9747 AA Groningen, the Netherlands
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Dr. Peter Dendooven has a broad experience in techniques for producing and manipulating radioactive ions, ion beams and atoms and in the detection of nuclear radiation. This experience has been gained in the fields of nuclear structure, inertial confinement fusion (ICF) and molecular imaging.
A study of reflection asymmetry in light actinide nuclei at the Institute for Nuclear and Radiation Physics, University of Leuven, Belgium, resulted in a PhD degree in 1992. During a subsequent 2-year post-doc appointment at Lawrence Livermore National Laboratory, U.S.A., new neutron and gamma-ray diagnostics for use in ICF were developed. The years 1994 to 2001 were spent as senior researcher at the Accelerator Laboratory of the Department of Physics, University of Jyväskylä, Finland, where the ion guide technique was further developed and nuclear spectroscopy experiments were performed, both in Jyväskylä and elsewhere. In 2001, Dr. Dendooven joined the KVI, University of Groningen, Netherlands, as a staff member. He is developing ion catcher devices based on cryogenic helium gas and superfluid helium. In recent years, attention has shifted to the development of novel time-of-flight positron emission tomography detector technology and new applications thereof (e.g. in proton therapy).
Dr
Peter Dendooven
(KVI, University of Groningen)
Dr
Dennis Schaart
(Delft University of Technology)
Mr
Frans Schreuder
(KVI, University of Groningen)
Prof.
Freek Beekman
(Delft University of Technology)
Prof.
Herbert Löhner
(KVI, University of Groningen)
Mr
Herman van Dam
(Delft University of Technology)
Mr
Martijn de Boer
(Delft University of Technology)
Mr
Ruud Vinke
(KVI, University of Groningen)
Mr
Stefan Seifert
(Delft University of Technology)
