Speaker
Silke Johannsen
Description
As one kind of non-canonical structures of nucleic acid, G-quadruplexes (G4) exist universally in the
genome of different organisms and in humans. G4 are supposed to play crucial regulatory roles in gene
replication, translation and expression. Therefore, G4s are handled as a promising target for chemotherapy. To date, most studies concentrated on DNA G4s, while the understanding of RNA G4s is far
from comprehensive. Here I will present our recent results on investigating structural details of RNA G4s
by NMR spectroscopy.
Primary author
Silke Johannsen
Co-authors
Simon Jurt
(Department of Chemistry, University of Zurich)
Zenghui Wang
(Department of Chemistry, University of Zurich)
Roland K.O. Sigel
(Department of Chemistry, University of Zurich)
