Jun 3 – 5, 2022
Parador El Saler, Valencia, Spain
Europe/Zurich timezone

Timing with (semi-)prompt photons: a review and perspective on the full detector chain

Jun 3, 2022, 5:15 PM
Parador El Saler, Valencia, Spain

Parador El Saler, Valencia, Spain

System considerations for pushing TOFPET CTR ≤ 100ps System considerations for TOFPET CTR resolution ≤100ps


Mr Nicolaus Kratochwil (CERN)


Accurate time estimation utilizing (semi-)prompt photons can benefit Time-of-Flight Positron Emission Tomography. However, we are limited to fewer detected photons with current state-of-the-art ultra-fast detectors, ultimately resulting in the pursuit of every single photon.

In the lab, this quest starts with light production (Cherenkov photons, quantum confinement luminescence etc), continues with the efficient light transport to the photodetector (high refractive index materials, photonic crystals, novel readout designs) over the photodetector (SPTR, PDE, correlated noise) and finishes with signal processing (low noise, high bandwidth electronics, fast ASIC, power consumption) and digitization. Finally, the measured data can be reconstructed to images using the appropriate TOF system response matrix. However, even the best time resolution does not achieve the desired image quality if quantities such as sensitivity, energy resolution, or depth-of-interaction are overlooked.

This contribution provides an extensive review of recent developments in fast timing with (semi-)prompt photons, emphasizing the whole radiation detector chain. In addition, we discuss system integration aspects, limits and paths for future detector improvements toward and below 100 ps CTR with PET-sized geometries.

Primary author


Mrs Fiammetta Pagano (CERN, Esplanade des Particules 1, 1211 Meyrin, Switzerland) Mrs Giulia Terragni (CERN, Esplanade des Particules 1, 1211 Meyrin, Switzerland) Prof. Sergio Gomez (Serra Hunter Fellow, Polytechnic University of Catalonia (UPC), Institute of Cosmos Sciences (ICCUB), University of Barcelona (IEEC-UB), Barcelona, Spain) Prof. Gerard Arino-Estrada (Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, United States of America) Mrs Katerina Decka (Faculty of Nuclear Sciences and Physical Engineering, Technical University, Brehova 7, 115 19 Prague, Czech Republic) Mr Philipp Mohr (FH Aachen University of Applied Sciences, Juelich,Germany) Dr Nikos Efthimiou (Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA) Prof. Marco Pizzichemi (CERN, Esplanade des Particules 1, 1211 Meyrin, Switzerland) Dr Stefan Gundacker (Department of Physics of Molecular Imaging Systems, Institute for Experimental Molecular Imaging, RWTH Aachen University, Forckenbeckstr. 55, 52074 Aachen, Germany) Dr Etiennette Auffray (CERN, Esplanade des Particules 1, 1211 Meyrin, Switzerland)

Presentation materials