Jun 3 – 5, 2022
Parador El Saler, Valencia, Spain
Europe/Zurich timezone

Novel biomarker and drug delivery systems for theranostics – extracellular vesicles

Jun 3, 2022, 12:30 PM
15m
Parador El Saler, Valencia, Spain

Parador El Saler, Valencia, Spain

Clinical motivation for pushing TOFPET CTR ≤ 100ps Clinical motivation for pushing TOFPET CTR resolution ≤100ps

Speaker

Ewa Stępień

Description

Extracellular vesicles (EVs) are nano- and micro-sized cell-derived entities, released from cells under physiological and pathological conditions [1]. EVs can be found in every biological fluid including blood, saliva, milk, or urine, serving as a liquid biopsy [2]. Their biological properties (cell-uptake, biocompatibility) [3], and chemical (composition, structure) or physical (size, density) [4] characteristics make EVs a good candidate for drug delivery systems (DDS). Recent advances in the field of EVs (e.g. scaling-up production, purification) and developments of new imaging methods (molecular imaging) revealed benefits of radiolabelled EVs in diagnostic and interventional medicine as a potential DDS in theranostics [5].

[1] Stępień E et al. Number of microparticles generated during acute myocardial infarction and stable angina correlates with platelet activation. Arch Med Res. 2012;43:31-5.
[2] Stępień EŁ et al. Circulating ectosomes: Determination of angiogenic microRNAs in type 2 diabetes. Theranostics. 2018;8:3874-3890.
[3] Stępień E et al. Microparticles, not only markers but also a therapeutic target in the early stage of diabetic retinopathy and vascular aging. Expert Opin Ther Targets. 2012;16:677-88.
[4] Stępień EŁ et al. Fourier-Transform InfraRed (FT-IR) spectroscopy to show alterations in molecular composition of EV subpopulations from melanoma cell lines in different malignancy. Biochem Biophys Rep. 2021;25:100888.
[5] Stępień EŁ, Rząca C, Moskal P. Novel biomarker and drug delivery systems for theranostics—Extracellular vesicles. Bio-Algorithms Med-Systems 2021:17:301–309

Primary author

Presentation materials