Speaker
Description
Time differential Perturbed Angular Correlation (PAC) of γ-rays spectroscopy may be applied to study the coordination geometry and dynamics at metal ion binding sites of proteins [1-2]. Selected examples relating to recent $^{199m}$Hg and $^{111}$Ag PAC experiments will be presented, such as 1) Ag(I) binding to human serum albumin - the major transport protein in blood; 2) A potential $^{111}$Ag reference sample (Ag-benzoate(s)); 3) Modelling the effect of recoil energy on local structure upon the $\beta$-decay of $^{111}$Ag [4]; 4) Hg(II) binding to an arsenic(III) biosensor - As(III) is one of the most important ubiquitous toxic elements in the environment.
References
[1] Hemmingsen L., Sas K.N., Danielsen E. Biological applications of perturbed angular correlation of gamma-rays (PAC) spectroscopy
Chem. Rev. 2004, 104, 4027-4062
[2] S. Chakraborty, S. Pallada, J.T. Pedersen, A. Jancso, J.G. Correia, and L. Hemmingsen Nanosecond dynamics at protein metal sites: An application of perturbed angular correlation (PAC) of γ-rays spectroscopy Acc. Chem. Res., 2017, 50, 2225-2232
[4] R. Fromsejer, K.V. Mikkelsen, L. Hemmingsen
Dynamics of nuclear recoil: QM-BOMD simulations of model systems following β-decay
Phys.Chem.Chem.Phys., 2021, 23, 25689-25698
