Speaker
Description
In humans, the nuclear genome is built of about 6 billion base pairs with protein coding elements constituting only about 1.5% of our genome. They encode about 19 to 21 thousand proteins – which is much less than one would expect considering our organismal complexity. But incredible variety is introduced at every level of protein production: from the regulation of gene expression to the processes of transcription and translation. And finally, during or post translation, additional modifications (PTMs) are made. These can alter protein function, cellular localization, or half-life, and thus are our body’s crucial tools in maintaining homeostasis. But as any tool, they might be misused, driving pathogenesis of numerous disorders. One of such modifications, carbamylation, is a non-enzymatic modification of lysines often encountered in, for example, chronic kidney disease. In this presentation I will show how carbamylation alters the regulation of renin-angiotensin system and hemostasis, hampering the functionality of blood vessels.
