Speaker
Description
The ability to convert ionic modalities to electrical signals has transformed our comprehension of biological phenomena, ranging from electromyography to recording postsynaptic potentials using the patch clamp technique. With the ongoing development of synthetic biology a variety of inducible gene expression systems have been engineered with possible applications in biosensors or inputs for genetic logic circuits. Such systems consist of a promoter and its cognate transcription factor that can either activate or repress the expression of its downstream genes in response to external stimuli like light, magnetism or osmolarity. Electrogenetic circuits transmit electronic information to engineered bacterial cells using redox molecules. The signal then controls the transcription from a simple synthetic gene circuit. The most commonly studied systems are based on the native transcriptional regulator SoxR and transcription from the PsoxS promoter which allows for a quick and scalable cell response. Furthermore, it presents with a variety of possible applications being able to induce bacterial motility and cell-to-cell communication.
[1] https://doi.org/10.1126/sciadv.abm5091
| Field | Biosciences |
|---|---|
| Length | Quick 10 min |
