11-15 February 2013
Vienna University of Technology
Europe/Vienna timezone

A PET TOF endorectal probe, compatible with MRI, for diagnosis and follow up of prostate and other pelvic region cancers

14 Feb 2013, 14:50
20m
Vienna University of Technology

Vienna University of Technology

Gußhausstraße 25-29, 1040 Wien (Vienna), Austria

Speaker

Dr Franco Garibaldi (INFN Roma1)

Description

Prostate Carcinoma, is a heterogeneous disease, asymptomatic to rapidly systemic malignancy. Standard techniques cannot detect early disease. An endorectal PET-TOF MRI probe would solve the problem. The internal probe has to be used in coincidence with external dedicated detectors and/or a standard PET. The performance of the probe dominates, with improvement in spatial resolution and efficiency. The electronics has to measure with a precision of 300 ps or less. The photodetectors have to be Silicon Photomultipliers (SiPM), for timing properties, compactness and MRI compatibility. Dual imaging agents PET allow for a trimodality imaging platform, helping in detecting limph nodes and tumor margins. Results from simulation show spatial resolution of ~1.5 mm for source distances up to 80 mm; the efficiency is significantly improved with respect to the external PET. A discrete electronics system, based on ASIC has been designed and built. Minidetectors have been built and tested. We obtained, for the first time, timing resolution of 300 ps and at the same time Depth Of Interaction (DOI) resolution of 1 mm or less. The proposed detector can be used for several dieases.. It is an advanced and innovative multimodality imaging molecular system of the pelvic region that will merge anatomical and metabolic details from (simultaneous) TOF-PET/MRI imagers for diagnosis and follow up of several cancers: Adenocarcinoma Endocervical, and Lynch Syndrome in women and Prostate cancer in men
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Primary author

Dr Franco Garibaldi (INFN Roma1)

Co-authors

Dr Angelo Rivetti (INFN Torino) Dr Francesco Cusanno (TUM) Dr Luigi Cosentino (LNS INFN) Dr Paolo Finocchiaro (INFN LNS) Dr Paolo Musico (INFN Genova)

Presentation Materials