Speaker
Prof.
Paul Francois
(McGill University)
Description
Many biological networks have to filter out useful information from a vast excess of spurious interactions. We use computational evolution to predict design features of networks processing ligand categorization. The important problem of early immune response is considered as a case-study. Rounds of evolution with different constraints uncover elaborations of the same network motif that we name "adaptive sorting". An instance of this module is present in mammalian T-cell biochemical networks. Analytical study of this motif unifies several puzzling properties of immune recognition, such as ligand antagonism and non-monotonic response time of immune response as a function of ligand concentration. It also predicts counter-intuitive loss of response at high ligand concentrations of foreign ligands for some parameter regime, which is checked experimentally.
Primary author
Prof.
Paul Francois
(McGill University)
Co-author
Mr
Jean-Benoit Lalanne
(McGill University)
