Name: ICTR-PHE 2016
Start: 2016-02-15T12:00:00+01:00
End: 2016-02-19T15:40:00+01:00
Location: Centre International de Conferences de Geneve (CICG)

ICTR-PHE 2016

from Monday, February 15, 2016 (12:00 PM) to Friday, February 19, 2016 (3:40 PM)

Monday, February 15, 2016
1:00 PM Welcome address and opening - Jacques Bernier (GSMN) Manjit Dosanjh (CERN) Eckhard Elsen (CERN)
Welcome address and opening
- Jacques Bernier (GSMN)
- Manjit Dosanjh (CERN)
- Eckhard Elsen (CERN)
1:00 PM - 1:30 PM
Room: 2
1:30 PM
1:30 PM - 4:45 PM
Contributions

1:30 PM A comprehensive omics approach for development of prognostic or predictive biomarkers in squamous cell carcinoma of the head and neck treated with radiation - Michael Story

2:00 PM What are the Dominant Radiobiological Mechanisms at Play in Stereotactic Radiotherapy? - David Brenner

2:30 PM The symbiosis of science of radiation biology with immunology: Impact on basic and translational research - Ahmed Mansoor

2:45 PM The relevance of DNA damage clustering on the nanometer and micrometer scale for the quantitative prediction of radiation effects - Michael Scholz

3:00 PM Correlation of Particle Traversals with Clonogenic Survival Using Cell-Fluorescent Ion Track Hybrid Detector - Ivana Dokic

3:15 PM Radiation induced DNA damage in human uveal melanoma cells - Katarzyna Jasińska

4:00 PM Quantum dots imaging tests on SPAD for nanodosimetric applications - Alberto Quaranta

4:15 PM Disruption of telomere equilibrium sensitises human cancer cells to DNA repair inhibition and radiation - Prakash Hande

4:30 PM Investigating the impact of a variable RBE on proton dose fractionation across an actively scanned spread-out Bragg peak - Kevin Prise
4:45 PM
4:45 PM - 6:00 PM
Contributions

4:45 PM Molecular imaging for theranostics - Wim Oyen

5:15 PM Early variation of FDG-PET radiomics features in NSCLC is related to overall survival - the “delta radiomics” concept - Ralph Leijenaar

5:30 PM How to produce scandium-44 and scandium-43 efficiently? - Charlotte Duchemin Jerzy Jastrzębski Katharina Domnanich
Tuesday, February 16, 2016
8:30 AM Nuclear Medicine
Nuclear Medicine
8:30 AM - 10:00 AM
Contributions

8:30 AM Quantitative Theranostics in Nuclear Medicine - Michael Lassmann

9:00 AM Manufacturing and Nuclear Medicine Applications of the Novel Isotope Sn-117m - Nigel Stevenson

9:15 AM Contribution of direct and bystander effects to therapeutic efficacy of alpha-RIT using ²¹²Pb-labeled mAbs - Jean-Pierre Pouget

9:30 AM 64Cu-Labeled Folate Radioconjugate for PET Imaging of Folate Receptor-Positive Tumors - Renata Farkas

9:45 AM Radiolabeled Acridine Orange (AO) Derivatives as DNA-Targeted Probes for Auger Therapy - Antonio Paulo
10:00 AM Coffee break
Coffee break
10:00 AM - 10:30 AM
Room: 2
10:30 AM
10:30 AM - 2:15 PM
Room: 2
Contributions

10:30 AM Imaging for online control of particle therapy - Thomas Bortfeld

11:00 AM First clinical application of a prompt gamma based in vivo proton range verification using a knife-edge slit camera - Christian Richter

11:30 AM New Results with Monolithic Scintillators for Time-of-Flight PET - Dennis Schaart

11:45 AM Development of a High Resolution Module for PET scanners - Gianluca Stringhini

12:00 PM J-PET: a novel TOF-PET scanner based on plastic scintillators - Pawel Moskal

12:15 PM Development of a radioguided surgery technique with beta- decays in brain tumor resection - Riccardo Faccini

1:30 PM Range Verification with Ionoacoustics: simulations and measurements at a clinical proton synchro-cyclotron - Sebastian Lehrack

1:45 PM Measurement of Acoustic Emissions Generated by a Pulsed Proton Beam from a Hospital-Based Clinical Cyclotron - Kevin Jones

2:00 PM Fast Beam Profile Monitors for Microbeam Radiation Therapy - Bjarne Stugu
2:15 PM New Technologies
New Technologies
2:15 PM - 3:45 PM
Contributions

2:15 PM MRI for external beam radiotherapy guidance - Jan Lagendijk

2:45 PM MRI Guided Proton Therapy: pencil beam scanning in an MRI fringe field - Brad Oborn

3:00 PM Nanoparticle Enhanced MRI-Guided Radiation Therapy: Final proof of concept before phase I trial - Shady Kotb

3:15 PM Hadron minibeam radiation therapy: feasibility study at the Heidelberg IonBeam Therapy Center (HIT) - Immaculada Martínez-Rovira

3:30 PM Evaluation of long-term effects of synchrotron-generated microbeams on rat hippocampal neurogenesis - Alberto Bravin
3:45 PM Coffee Break
Coffee Break
3:45 PM - 4:15 PM
Room: 2
4:15 PM
4:15 PM - 5:30 PM
Contributions

4:15 PM Big Data in Radiation Oncology: data gathering, data processing, algorithms and clinical impact - Klaus Maier-Hein

4:45 PM Expert knowledge and data-driven Bayesian Networks to predict post-RT dyspnea and 2-year survival - Timo Deist

5:00 PM Dosimetry of ultra high dose rate irradiation for studies on the biological effect induced in normal brain and GBM - Kristoffer Petersson

5:15 PM Geant4 coupled with Comsol heat transfer simulations to determine correction factors of a novel micro-calorimeter - Kamran Fathi
6:30 PM Public talk - Sound for Health - Domenico Vicinanza - Domenico Vicinanza
Public talk - Sound for Health - Domenico Vicinanza
- Domenico Vicinanza
6:30 PM - 7:30 PM
Room: 2
Wednesday, February 17, 2016
8:30 AM
8:30 AM - 9:00 AM
Contributions

8:30 AM How emerging trends in basic research & technology will shape clinical research? - Eric Deutsch
9:00 AM
9:00 AM - 10:00 AM
Room: 2
Contributions

9:00 AM Is Distributed learning the solution for Rapid Learning Health Care? - Philippe Lambin

9:30 AM Biological stratification in times of highly conformal radiotherapy - status and perspectives - Michael Baumann
10:00 AM Coffee and poster viewing
Coffee and poster viewing
10:00 AM - 11:00 AM
11:00 AM Plenary
Plenary
11:00 AM - 12:00 PM
Contributions

11:00 AM Biological issues and their clinical implications in proton therapy - Radhe Mohan

11:30 AM Single particle detection for spectroscopic CT and tracking in hadron therapy using Medipix chips - Michael Campbell
12:00 PM Lunch & Exhibitor presentations
Lunch & Exhibitor presentations
12:00 PM - 1:00 PM
1:00 PM
1:00 PM - 2:15 PM
Room: 2
Contributions

1:00 PM New hypoxia probe development based on mass spectrometry - Brad Wouters

1:25 PM The role of functional imaging for radiation oncology – The whole translational chain from animals to clinics - Esther Troost

1:50 PM Is dual energy CT the next standard imaging modality for radiotherapy? - Wouter van Elmpt
1:00 PM - 2:15 PM
Room: 3
Contributions

1:00 PM Proton Radiation Therapy: Current Status at Massachusetts General Hospital - Thomas DeLaney

1:25 PM MedAustron - status and vision - Eugen Hug

1:50 PM Particle therapy centre in Shanghai - Zhen Zhang
1:00 PM - 2:15 PM
Room: 4
Contributions

1:00 PM Urethra-sparing SBRT for prostate cancer: dosimetric optimization with VMAT vs. IMRT and the learning curve effect - Thomas Zilli

1:15 PM A novel method to predict a priori the toxicity reduction of a prostate-rectum spacer: Virtual Rectum Spacer - Ben Vanneste

1:30 PM Local Tumor Flare Following Radiosurgery and Ipilimumab (Ipi) for Melanoma Brain Metastases: Increased Immune Response? - Caroline Chung

1:45 PM Response-based Bayesian Network Approaches for Adaptive Radiotherapy of Non-Small Cell Lung Cancer (NSCLC) - Randall Ten Haken

2:00 PM Further Development of Spinal Tissue Radiotherapy Re-treatment Modelling, with inclusion of Hadrontherapy - Bleddyn Jones
2:15 PM
2:15 PM - 3:45 PM
Room: 4
Contributions

2:15 PM Proton Minibeam Radiation Therapy (pMBRT): implementation at a clinical center - Cécile Peucelle

2:25 PM Investigation of the use of inhomogeneous fractional dose distributions in IMPT to improve the therapeutic index - Lorenzo Manganaro

2:35 PM Accuracy of portal dosimetry in hybrid IMRT and VMAT treatment of the prostate - James Bedford

2:45 PM ODSH as a countermeasure for radiation-induced thrombocytopenia: Dosimetric studies - Stephen Avery

2:55 PM Measurements of Reactive Oxygen Species production induced by Gold Nanoparticles in Radiotherapy protoco - Piergiorgio Cerello

3:05 PM NanoxTM: A new multiscale theoretical framework to predict cell survival in the context of particle therapy - Micaela Cunha

3:15 PM Simulation of cell survival for proton broad and minibeam radiotherapy with hexagonal and square minibeam alignment - Matthias Sammer

3:25 PM Microbeam Radiation Therapy (MRT): achievements and future perspectives - Elke Bräuer-Krisch

3:35 PM The role of adipose stromal cells for reversal of radiation fibrosis - Fei-Fei Liu
Optimizing treatment planning and delivery
Optimizing treatment planning and delivery
2:15 PM - 3:55 PM
Room: 3
Contributions

2:15 PM Current and future strategies developed at Paul Scherrer Institute - Alessandra Bolsi

2:40 PM Optimizing prostate cancer irradiation: from technology to fractionation - Raymond Miralbell

3:05 PM Technological advancement in radiation oncology - Hak Choy

3:30 PM Main challenges in adaptive radiotherapy - Jan-Jakob Sonke
Therapeutic targets: towards the cutting edge
Therapeutic targets: towards the cutting edge
2:15 PM - 3:55 PM
Room: 2
Contributions

2:15 PM The Biology of Single Dose Radiotherapy - Zvi Fuks

2:40 PM Are there common signaling pathways among highly radioresistant tumors? The examples of high grade gliomas and sarcomas - Elizabeth Moyal

3:05 PM HIF-related therapeutic windows - Amato Giaccia

3:30 PM Vascular disrupting agents: a new avenue of research - Michael Horsman
3:55 PM Coffee break
Coffee break
3:55 PM - 4:30 PM
4:30 PM
4:30 PM - 5:45 PM
Room: 2
Contributions

4:30 PM Oncolytic viruses - Kevin Harrington

4:55 PM Synergy of radiotherapy and cancer vaccines in HPV-positive tumors - Eric Deutsch

5:20 PM Radiotherapy and the immunocytokine L19-IL2: a perfect match for an abscopal effect with long-lasting memory - Ludwig Dubois
4:30 PM - 5:45 PM
Room: 3
Contributions

4:30 PM Pelvic tumor irradiation: new tools to reduce toxicity: from technology to drugs - Karin Haustermans

4:55 PM Towards a new type of irradiation - Jean Bourhis

5:20 PM Treatment outcome in patients treated with single-dose irradiation (SDRT) for oligometastatic disease - Carlo Greco
4:30 PM - 5:45 PM
Room: 4
Contributions

4:30 PM Geometrical interpretation of TOF PET raw data in commercial PET-CT scanner for SNR optimization - Chiara Gianoli

4:45 PM Characterization and test beam results of a LaBr3 Compton Telescope for treatment monitoring - Gabriela Llosá

5:00 PM Small Large Momentum Acceptance Gantries for Proton and Carbon Cancer Therapy - Dejan Trbojevic

5:15 PM X-Ray Phase contrast micro-imaging in neuroscience - Giacomo Barbone

5:30 PM Water based 3D optical dose imaging for particle therapy - Oksana Kavatsyuk
7:00 PM Gala dinner with Keynote by Vytenis Andriukaitis, EC Health Commissioner
Gala dinner with Keynote by Vytenis Andriukaitis, EC Health Commissioner
7:00 PM - 9:00 PM
Thursday, February 18, 2016
8:15 AM
8:15 AM - 8:50 AM
Room: 2
Contributions

8:15 AM Multimodality Precision Medicine - Søren Bentzen
8:50 AM
8:50 AM - 10:05 AM
Room: 3
Contributions

8:50 AM The search for genetic predictors of radiotherapy response - Dirk De Ruysscher

9:15 AM RSI: A genomic signature of radiosensitivity - Peter A. Johnstone

9:40 AM Radiomics in Liquid Biopsies - Frederic Zenhausern
Clinical Trials for particle therapy
Clinical Trials for particle therapy
8:50 AM - 10:05 AM
Room: 2
Contributions

8:50 AM Trials in USA - James Cox

9:15 AM Trials in Germany - Jürgen Debus

9:40 AM Clinical trials for carbon-ion radiotherapy in Japan - Hirohiko Tsujii
10:05 AM Coffee break
Coffee break
10:05 AM - 10:30 AM
10:30 AM
10:30 AM - 12:10 PM
Room: 2
Contributions

10:30 AM Radiotherapy quality assurance platform of the EORTC - Damien Weber

10:52 AM Radiotherapy quality assurance platform of the EORTC - André Branquinho

11:02 AM Synergy of targeted agents and radiotherapy - Sofia Rivera

11:24 AM Lessons from translational research in EORTC Glioma trials - Monika Hegi

11:46 AM Data from the EORTC Cancer Survivorship Task Force - Conny Vrieling
10:30 AM - 11:45 AM
Contributions

10:30 AM Study of the radiation produced by therapeutic He, C and O ion beams impinging on a PMMA target - Alessio Sarti

10:45 AM Short-lived Positron Emitters in Beam-on PET ImagingDuring Proton Therapy - Tom Buitenhuis

11:00 AM DoPET: an in-treatment monitoring system for particle therapy - Valeria Rosso

11:15 AM Commissioning of a Compton camera for ion beam range verification via prompt gamma detection using low-energy and clinical particle beams - Saad Aldawood

11:30 AM Prompt Gamma-ray Timing experiment during different modalities of proton beam delivery - Thomas Kormoll
10:30 AM - 12:00 PM
Room: 4
Contributions

10:30 AM The effect of fractionated administration of thalidomide at γ-ray irradiation on tumor response and lung metastasis - Shin-ichiro Masunaga

10:45 AM Predictive Biomarkers for Improving Radiation Therapy - Pataje Prasanna

11:00 AM Targeted Radionuclide Therapy with 161Tb: Investigation of Anti-Tumor Effects and Undesired Side Effects - Cristina Müller

11:15 AM The relationship between absorbed dose and DNA Damage in Lymphocytes after radionuclide therapy - Uta Eberlein

11:30 AM Modeling the effect of symmetrical division of cancer stem cells on tumour response to radiation - Loredana Marcu

11:45 AM A dose response analysis of the patients treated with Boron Neutron Capture Therapy (BNCT) in Finland in 1999 to 2011 - Hanna Koivunoro
12:00 PM

12:00 PM - 1:00 PM
1:00 PM
1:00 PM - 1:30 PM
Room: 2
Contributions

1:00 PM Tackling Phenotypic Diversity to Increase Cures - Brad Wouters
1:30 PM
1:30 PM - 2:45 PM
Room: 3
Contributions

1:30 PM Novel anti-tumor agents targeting cell membrane - Marcel Verheij

1:55 PM Stroma mediated wound healing signals and cell response to radiation - Marie-Catherine Vozenin

2:20 PM Targeting tumor heterogeneity - Gerben Borst
1:30 PM - 2:45 PM
Contributions

1:30 PM Towards analytic dose calculation for MR guided particle beam therapy - Hermann Fuchs

1:45 PM Experimental dosimetric comparisons of protons, helium, carbon and oxygen ion beams - Thomas Tessonnier

2:00 PM Implementation of an analytical solution to lateral dose prediction in a proton therapy treatment planning system - Valentina Elettra Bellinzona

2:15 PM Utilizing CBCT data for dose calculation in adaptive IMPT - Christopher Kurz

2:30 PM Can we replace high quality simulation CT by simple kV-cone-beam CT images to extract an externally validated radiomics signature? - Janita van Timmeren
1:30 PM - 2:45 PM
Room: 2
Contributions

1:30 PM In-vitro RBE - Marco Durante

1:55 PM Carbon ion radiotherapy: do we understand each other? How to compare differentt RBE-weighted dose systems in the clinical setting - Piero Fossati

2:20 PM Physics and RBE - Tony Lomax
2:45 PM Coffee and poster viewing
Coffee and poster viewing
2:45 PM - 4:15 PM
4:15 PM
4:15 PM - 5:30 PM
Room: 3
Contributions

4:15 PM Emerging challenges in combating cancer - Norman Coleman

4:40 PM Targeted Treatment for the Non- Small Cell Lung Cancer - Ritsuko Komaki

5:05 PM Magnetic resonance temperature imaging in clinical hyperthermia: past experience and prospects - Peter Wust
4:15 PM - 5:30 PM
Room: 2
Contributions

4:15 PM Current status of particle therapy at CNAO - Roberto Orecchia

4:40 PM Integration of economic data in clinical trials - Yolande Lievens

5:05 PM Current status of particle therapy in The Netherlands - Hans Langendijk
4:15 PM - 5:30 PM
Room: 4
Contributions

4:15 PM Radiation treatment monitoring using multifunctional imaging in prostate tumour xenografts - Natalia Arteaga-Marrero

4:30 PM Robustness and reliability of PET-based identification and quantification of tumor hypoxia, using simple static or more complex scan acquisitions - Morten Busk

4:45 PM Variable RBE in proton therapy: comparison of model predictions and their impact on clinical-like cranial lesions - Julia Bauer

5:00 PM Inhibiting the actions of cathepsin L effects both tumour initiation and metastasis formation - Thomas Wittenborn

5:15 PM Plerixafor Improves Local Control and Reduces Metastases in Cervical Cancer Treated with Radiotherapy and Chemotherapy - Michael Milosevic
Friday, February 19, 2016
8:30 AM
8:30 AM - 9:45 AM
Contributions

8:30 AM Genetic and pharmacological inhibition of autophagy after irradiation - Kasper Rouschop

8:55 AM Oncometabolite lactate promotes tumour growth - Pierre Sonveaux

9:20 AM Determining cell radiosensitivity using assays in ex vivo irradiated tumour specimens - Daniel Zips
8:30 AM - 9:45 AM
Room: 3
Contributions

8:30 AM MEDICIS-PROMED : a ITN Marie-Curie network on nuclear medicine and 11C-based hadron-therapy - Johanna Pitters

8:40 AM MEDICIS-PROMED: MEDICIS-Produced Radioisotope Beams for Medicine an Innovative Training Network - John Prior

9:05 AM Recurrent glioblastoma multiforme – targeted alpha therapy with 213Bi-DOTA-Substance P - Frank Bruchertseifer

9:25 AM Medical isotope production at TRIUMF and future collaboration with MEDICIS-PROMED - Yann Seimbille
8:30 AM - 9:40 AM
Contributions

8:30 AM Comparison of Arterial Input Functions by Magnitude and Phase Signal Measurement in DCE MRI of brain cancer patients - Catherine Coolens

8:40 AM Fast calibration of the range of Carbon ionswith in-beam PET of Boron-8 nuclei - Caterina Cuccagna

8:50 AM An online beam monitor detector for medical applications of ion beams - Saverio Braccini

9:00 AM The GEMPIX detector for energy deposition measurements in Hadrontherapy - Fabrizio Murtas

9:10 AM GPU based iterative CBCT for prospective motion compensated algorithm for radiation therapy - Ander Biguri

9:20 AM Measurements and simulations of in-phantom neutron dose from a proton pencil beam - Kristian Ytre-Hauge

9:30 AM CHIC – A Multi-scale Modelling Platform for in-silico Oncology - Daniel Abler
9:45 AM Coffee break
Coffee break
9:45 AM - 10:15 AM
10:15 AM
10:15 AM - 11:25 AM
Room: 4
Contributions

10:15 AM Clinical validation of the M5L lung Computer-Assisted Detection system - Piergiorgio Cerello

10:25 AM Tuning of a 4D ML reconstruction strategy for treatment verification in ion beam radiotherapy - Katia Parodi

10:35 AM Differential cross sections measurements for hadrontherapy: 50 MeV/n 12C reactions on H, C, Al, O and natTi targets - Clovis Divay

10:45 AM Metal implanted multi-functional nanovectors for targeted radiotherapy and diagnostics of cancer - Asénath Etilé

10:55 AM The Malthus Project - updated predictions of national radiotherapy demand to 2030 - Thomas Mee

11:05 AM The use of radiobiological TCP and NTCP models to validate the dose calculation algorithm and readjust the prescribed dose - Jacques Balosso

11:15 AM Status of the CaLIPSO High-Resolution PET Project - Xavier Mancardi
10:15 AM - 11:25 AM
Contributions

10:15 AM The use of 149Tb and 152Tb in preclinical investigations: an update on its mass separation and subsequent application for imaging and therapy - Nicholas van der Meulen

10:25 AM Design of electronic data processing system for radiotherapy study: lessons learned from VoxTox - Marina Romanchikova

10:35 AM Assessment tool to quantify and visualize treatment plan robustness regarding patient setup - Michael Fix

10:45 AM A Hypercellular Component of Glioblastoma Identified by High b-value Diffusion Weighted Imaging - Yue Cao

10:55 AM Treatment of moving targets with active scanning carbon ion beams - Piero Fossati

11:05 AM Distributed learning: predictive models based on data from multiple hospitals without data leaving the hospital - Arthur Jochems

11:15 AM A clinical protocol for Simultaneous Integrated Boost for proton treatment of Head and Neck carcinoma - Francesca Belosi
OPENMED
OPENMED
10:15 AM - 11:30 AM
Room: 2
Contributions

10:15 AM Conceptual Design report for OpenMED - Ghislain Roy

10:40 AM OPENMED: Topics, Issues and Wishes - Mike Waligórski

11:05 AM Role of the CERN International Strategy Committee in the LEIR initiative: Biology - Philippe Lambin
11:30 AM Poster viewing
Poster viewing
11:30 AM - 12:00 PM

12:00 PM Lunch
Lunch
12:00 PM - 12:45 PM
12:45 PM Panel discussionTargeting Strategies
Panel discussionTargeting Strategies
12:45 PM - 2:00 PM
Room: 2
Contributions

12:45 PM Multimodal approach to assess tumour vasculature and potential treatment effect - Dag Rune Olsen

1:10 PM Hypoxia-guided adaptive radiation dose escalation in head and neck carcinoma - Vincent Gregoire

1:35 PM Microtubule-stabilizing agents with inhibitors of angiogenesis to overcome resistance - Martin Pruschy
12:45 PM - 2:00 PM
Room: 3
Contributions

12:45 PM Orthotopic tumor models for glioma and NSCLC - Jan Theys

1:10 PM High Performance Preclinical Irradiation Through Optimized Dual Focal Spot Dose Painting and Online Virtual Isocenter Radiation Field Targeting - David Jaffray

1:35 PM Studying radiotherapy resistance of BRCA1-mutated mammary tumors - Sven Rottenberg
12:45 PM - 2:00 PM
2:00 PM
2:00 PM - 3:15 PM
Room: 3
Contributions

2:00 PM Balanced checkpoint activation: genomic stability and cell response to radiation - Simon Powell

2:25 PM Macrophage reprogramming for anticancer therapy - Michele De Palma

2:50 PM Focal adhesion signaling and therapy resistance in cancer - Anne Vehlow
2:00 PM - 3:15 PM
Contributions

2:00 PM Factors of radioresistance in prostate cancer - Mechthild Krause

2:25 PM Targeting NOTCH pathway in Glioblastoma - Marc Vooijs

2:50 PM Human Sphingolipid Biomarkers of Single Dose Radiotherapy: A Clinical trial - Richard Kolesnick
3:15 PM

3:15 PM - 3:40 PM
Room: 2

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