Fermilab is collaborating with industry and other labs and universities on superconducting (SC) wire and cable R&D, with the goal of improving key properties and providing conductor specifications and data for design and construction of SC accelerator magnets for a future very high energy pp collider. SC wire R&D focused first on optimizing the geometrical and chemical layout of Restacked-Rod Process conductor by Bruker OST. Then, efforts were intensified on research to improve Nb3Sn inherent flux pinning by producing artificial pinning centers in the Nb3Sn phase, which refines grain size to 30 nm. In parallel, FNAL is collaborating with a number of companies to develop Nb3Sn wires with increased specific heat to improve conductor stability and reduce sensitivity to external perturbations. Rutherford cable development includes heat treatment studies to boost performance of existing cables, and innovative design ideas for larger cables, which are preferred for 16 T magnets with appropriate operational margin. This presentation will give an overview of the various SC R&D activities at Fermilab and their associated results.