Feb 17 – 21, 2025
Vienna University of Technology
Europe/Vienna timezone

New high-Z organic scintillators for total-body SPECT and theranostic dosimetry

Feb 18, 2025, 3:40 PM
50m
Vienna University of Technology

Vienna University of Technology

Gusshausstraße 27-29, 1040 Wien
Board: 57
Poster Medical Applications Coffee & Posters A

Speaker

Mattia Bonuso (CREF-INFN)

Description

SPECT (Single-Photon Emission Computed Tomography) is a nuclear imaging diagnostic exam that involves the administration of a radiopharmaceutical that specifically links to the tumor cells while emitting gamma rays, allowing for cancer detection. Typical SPECT detectors involve monolithic inorganic crystals combined with PMT matrices for the readout.
In this contribution we present a new total-body SPECT gamma detector that exploits organic scintillators enriched with high-Z impurities with concentrations up to 10%, to profit from an extremely fast scintillation signal, low cost and ease of manipulation while ensuring the photoelectric interaction probability needed for good diagnostic efficiency. The reSPECT detection system will consist of a 3D-printed tungsten collimator that also serves as a container for the scintillator segments organized in a grid geometry. A custom readout based on the CMOS technology and tuned for fast scintillation events, with an independent channel for each scintillator, will be designed to handle the high event rate, allowing for possible applications in advanced theragnostic. Multiple FPGA-based modules will pre-process the data in real-time. Additionally, the Silicon-based readout guarantees the compliance with MRI scans.
In this contribution we will show the expected performances of the reSPECT detection system, evaluated with Monte Carlo simulations, and the results of the experimental tests carried out with the scintillator prototypes.

Authors

Alberto Burattini (Postgraduate School in Medical Physics, Sapienza University of Rome) Alessio Sarti (Sapienza Universita e INFN, Roma I (IT)) Angelica De Gregorio (INFN - National Institute for Nuclear Physics) Angelo Schiavi (Università di Roma "La Sapienza") Annalisa Muscato (INFN - Postgraduate School in Medical Physics, Sapienza University of Rome) Daniele Rocco (SBAI Department, Sapienza University of Rome) Enrico Manuzzato (FBK - Sensors and Devices, IRIS Research Unit, Povo (TN), Italy - Department of Information Engineering and Computer Science, University of Trento) Flaminia Quattrini (SBAI Department, La Sapienza University of Rome - INFN) Gaia Franciosini (Dipartimento di scienze di base e applicate per l'ingegneria, Sapienza, University of Rome - INFN) Giacomo Traini (INFN Istituto Nazionale di Fisica Nucleare - Sezione Roma I) Giuseppe De Vincentis (Department of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome) Dr Leonardo Gasparini (Fondazione Bruno Kessler) Leonardo Mattiello (SBAI Department, Sapienza University of Rome) Marco Garbini (“Enrico Fermi” Historical Museum of Physics and Study & Research Centre – CREF, Via Panisperna 89a, Rome, 00184, Italy - INFN) Marco Magi (SBAI Department, Sapienza University of Rome - INFN) Marco Toppi (INFN e Laboratori Nazionali di Frascati (IT)) Maria Silvia De Feo (Department of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome) Marina Carruezzo (Sapienza University of Rome) Marta David (“Enrico Fermi” Historical Museum of Physics and Study & Research Centre – CREF, Via Panisperna 89a, Rome, 00184, Italy) Mattia Bonuso (CREF-INFN) Michela Marafini (CREF-INFN) Nils Krah (University of Lion, CNRS, CREATIS, Lyon, France) Roberto Passerone (Department of Information Engineering and Computer Science, University of Trento) Vincenzo Patera (SBAI Department, Sapienza University of Rome - INFN) Viviana Frantellizzi (Department of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome)

Presentation materials