P. Lecoq, CERN
(CERN)
5/1/16, 2:00 PM
R. Draghia-Akli, EU-DG Research
(EU-DG Research)
5/1/16, 2:15 PM
R. Pettigrew, NIBIB-NIH, USA
5/1/16, 3:00 PM
M. Chlebus, EFPIA Brussels
5/1/16, 4:15 PM
M. Cirilli, CERN
5/1/16, 5:00 PM
J. Prior, CHUV Lausanne
(CHUV University Hospital)
5/1/16, 5:20 PM
This presentation will show actual and upcoming applications of nuclear medicine and molecular imaging for minimizing medical and surgical interventions. There are several ways nuclear medicine and molecular imaging can do this: (1) early detection of potentially lesion (rule-in/rule-out); (2) easier targeting of biopsies; (3) better detection of micro-metastases and tumor margins during...
G. Traini, Sapienza Univ. Roma
5/1/16, 5:50 PM
N. Navab, TU Münich
5/1/16, 6:10 PM
O. Ratib, HUGE, Geneva
5/2/16, 8:30 AM
F. Scopinaro, Sapienza Univ. Roma1
(Sapienza University of Rome)
5/2/16, 9:00 AM
Oral
Prostate cancer is the most common malignancy among males of developed countries. Several methods of diagnosis, staging and therapy have been recently studied : among them radio isotope methods are growing and probably are helping personalization and tailoring of treatment.
Tailoring is important in PCa because High and low risk, neuroebdocrine or glandular, hormone therapy responsive or...
F. Haddad, Subatech & ARRONAX
(Subatech and GIP ARRONAx)
5/2/16, 9:20 AM
Oral
Radioisotopes can be used in different field of medicine like oncology, neurology and cardiology. Different types of applications are possible thanks to the different kind of radiation available through the radioactive decay of nucleus. Gammas which are penetrating radiation are used for imaging to help diagnosis whereas charged radiations are used for therapy to destroy cells.
Only few...
M. Seimetz, I3M Valencia
(Instituto de Instrumentación para Imagen Molecular (I3M))
5/2/16, 9:40 AM
Oral
Many diagnostic methods are based on the use of tracers labelled with radioactive isotopes. Their production in centralised facilities and delivery to local health centres imply strong constraints to the isotope half lives. For this reason, more than 90% of all PET interventions are based on F-18 at present. The on-site synthesis of short-lived tracers containing C-11, O-15, or N-13 would...
D. García-Juan, Quibim SL
(Quibim SL)
5/2/16, 10:30 AM
Oral
Prostate cancer (PC) is the second most diagnosed type of cancer and the fifth leading cause of cancer-related death in men worldwide (most frequent cause of cancer death in men in developed countries).
Guidelines about prostate magnetic resonance (MR) imaging published by the European Society of Urogenital Radiology (ESUR) in 2012 recommended a multi-parametric approach for a better...
S. Vandenberghe, Ugent
(Ugent)
5/2/16, 10:50 AM
Oral
Targeted radionuclide therapy (TRT) is an established cancer treatment modality. It relies on cancer specific agents that are labeled with radionuclides for internal radiotherapy. The biological effect to tissues is generated by the energy absorbed from the radiation (typically beta-emittors) emitted by the radionuclide, TRT can result in substantial sparing of uninvolved tissue and organs and...
Prof.
R. Zboril, Olomuk Univ. (Cz)
(Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, PalackýUniversity Olomouc, Tř. 17. listopadu 12, 771 46 Olomouc, Czech Republic)
5/2/16, 11:10 AM
Oral
Nanomaterials based mainly on polymer nanostructures, magnetic nanoparticles and carbon nanoallotropes represent challenging solution in various diagnostic, therapeutic and theranostic applications [1-6]. The present contribution explores the use of superparamagnetic nanoparticles as contrast agents in MRI diagnostics and theranostics involving the results of clinical trials. Various types of...
N. Navab, TU Münich
5/2/16, 11:20 AM
Alberto Di Meglio
(CERN)
5/2/16, 11:50 AM
Oral
The transformations that have taken place in Information and Communication Technology in the past 20 years have given rise to a new form of scientific research paradigm where data-intensive, large-scale projects combine experiment, theory and computing to address fundamental questions about ourselves and our universe. The large-scale computing and data analysis infrastructure set up by the...
D. Visvikis, INSERM France
5/2/16, 12:10 PM
Homer H. Pien, Phillips
(Philips)
5/2/16, 2:00 PM
Oral
Healthcare around the world is undergoing dramatic transformations, due primarily to the unsustainable rate of growth in the cost of care. In response, the community must provide better care at a lower cost. Personalized medicine plays an integral part in that.
At Philips we are pursuing a strategy in precision health, which links across the entire care continuum from monitoring of...
M. Conti, Siemens Healthcare
(Siemens Healthcare)
5/2/16, 2:30 PM
Oral
We will review the new trends and the exciting future developments of molecular imaging, and relate them to how the industry can enable and strengthen these new directions.
1)Enabling new trends:
i)Theranostics and its role in personalized medicine, and the associated requirements on present and future generations of PET scanners
ii)Beyond “generic” FDG imaging, new specific tracers and...
S. Tavernier, PETSys
(Vrije Universiteit Brussel (BE))
5/2/16, 3:00 PM
Oral
CERN is one of the world's best centres for fundamental research. However, the economic return has been disappointingly low. I have been active in the field of technology transfer from fundamental research in high-energy physics to other fields during the last 20 years, and this activity culminated in the creation of a spin-off company a few years sago.
I will analyse the reason for the low...
B. Wiestler, Dept. of Neuroradiology, TU Munich
(Dept. of Neuroradiology, TU Munich, Germany)
5/2/16, 4:10 PM
Glioblastoma (WHO grade IV) is the most common malignant primary brain tumor in adults with a dismal median overall survival of 16 months, despite intensive radio-chemotherapy. In recent years, the advent of high-throughput genomic analyses has helped us to better understand the biology underlying this disease. These advances translate in two ways “from bench to bedside”: First, tumors now can...
A. Del Guerra, Dept. of Physics, University of Pisa
(Dept. of Physics, University of Pisa)
5/2/16, 4:40 PM
TRIMAGE is an interdisciplinary FP7-funded European collaboration aimed at developing a cost-effective dedicated brain PET/MR/EEG brain scanner for early diagnosis of schizophrenia. The brain activity measured with fMRI, combined with the highly sensitive molecular information provided by PET, and the highly sensitive temporal information from EEG converge into a new imaging tool for...
J. Silva-Rodríguez, IDIS Santiago de Compostela
(Molecular Imaging Group in Health Research Institute (IDIS), Santiago de Compostela, Galicia, Spain)
5/2/16, 5:00 PM
Multi-modal preoperative evaluation with advanced structural, functional, and metabolic neuroimaging techniques is essential in the pre-surgical evaluation of refractory epilepsy for the delineation of the epileptogenic zone to be resected. In latter years, PET has gained a leading role in this evaluation since it has demonstrated to be simpler and more sensitive than ictal SPECT in certain...
A. Gonzalez Martinez, I3M Valencia
5/2/16, 5:20 PM
The first prototype of the MINDView project, a brain PET insert MR compatible, is currently being assembled. The scanner is composed of 3 rings of 20 detector blocks each. The detector block includes a monolithic LYSO crystal with 50x50x20 mm3 and a custom 12x12 SiPM array (TSV-type). The system defines an axial and transaxial field of view (FOV) of about 150 mm and 240 mm, respectively....
J.M. Benlloch, I3M Valencia
5/2/16, 5:40 PM
A. Del Guerra, Dept. of Physics, University of Pisa, Italy
(Dept. of Physics, University of Pisa, Italy)
5/3/16, 8:30 AM
Positron Emission Tomography (PET) is a well established imaging technique for in vivo molecular imaging. After a brief history of PET, the physical principles and the main performance parameters are presented. The evolution of the technology that has brought PET from a bench experiment to a clinical indispensable instrument is fully illustrated. In particular, the present limitations and the...
C. Morel, CNRS, France
(Centre National de la Recherche Scientifique (FR))
5/3/16, 9:00 AM
Since the invention of the CAT scan by Hounsfield in the early 1970s, transmission and emission imaging modalities used in radiology and nuclear medicine have continually benefit from improvements in detection technology, signal treatment and applied mathematics. The development of 3D PET in the late 1980s, and of positron rotating partial-ring tomographs leaving potentially enough void...
C. Levin, Stanford, USA
5/3/16, 9:30 AM
M. Schwaiger, Nuclear Medicine, TU Münich
5/3/16, 10:30 AM
Multimodality imaging has become an attractive tool of cardiovascular imaging, delineating cardiac structures with high spatial resolution combined with specific metabolic and molecular information provided by tracer techniques. PET/CT offers the opportunity of non-invasive coronary angiography and myocardial perfusion imaging, linking anatomic definition of coronary stenosis with the...
Alexis A. Moscoso, IDIS Santiago de Compostela
(IDIS Santiago Compostela)
5/3/16, 11:00 AM
Introduction: different quantitative parameters estimated from PET and dedicated breast PET images have been proposed in order to describe heterogeneity in tumors, which could have predictive value in breast cancer. However, existing studies have not reached agreement on the predictive performance, in particular for textural features and other heterogeneity-related parameters. We have carried...
E. Auffray Hillemanns, CERN
(CERN)
5/3/16, 11:20 AM
In 2001, crystal clear launched a program to develop a dedicated breast positron tomograph. We will present the results of the first prototypes and the recent development of new crystal modules.
M. Pizzichemi, Universita Milano-Bicocca & INFN, (IT)
(Universita & INFN, Milano-Bicocca (IT))
5/3/16, 11:40 AM
The EndoTOFPET-US collaboration is developing a multi-modal imaging tool combining Ultrasound with Time-Of-Flight Positron Emission Tomography into an endoscopic imaging device. The objective of the project is to obtain a coincidence time resolution of about 200ps FWHM and to achieve ~1mm spatial resolution for the PET head, while integrating all the components in a very compact detector...
G. Llosa Llacer, IFIC - Valencia
(IFIC - Valencia)
5/3/16, 2:00 PM
Oral
The detection of prompt gammas to assess range variations in real time during hadron therapy is being investigated as an alternative to PET techniques. The use of prompt gammas can be advantageous given the larger amount produced as compared to positron emitters and the fact that they are produced within nanoseconds after irradiation. However, their detection is challenging due to the...
Giacomo G. Traini, Univ.Sapienza, INFN Roma1
(Università La Sapienza, INFN Roma1 (IT))
5/3/16, 2:20 PM
Oral
In Charged Particle Therapy (CPT) beams of protons or carbon ions are used for treatment of tumors. The higher precision in dose deposition achieved by charged ions with respect to X-Rays, used in conventional radiotherapy, allows to reduce the undesired dose released to the healthy tissues surrounding the cancer region. This makes the CPT particularly suitable for deep situated tumors close...
S. Vinogradov, Lebedev Physical Institute, Moscow
(Lebedev Physical Institute)
5/3/16, 2:40 PM
Oral
Hadrontherapy is an emerging technology toward personalized high precision medicine, a vital instrumentation, especially in a cancer treatment. Success in the treatment critically depends on the precision of gamma imaging in general and absorbed dose profile monitoring in particular. PET and SPECT are well-established modalities of gamma imaging, and both of them have specific advantages and...
P. Cerello, INFN Torino
(INFN Torino (IT))
5/3/16, 3:00 PM
Oral
In-beam PET is one of the options for real-time monitoring of the Bragg peak
depth in hadron-therapy sessions, which would allow hypofractionation and
the treatment of multiple lesions.
The INSIDE collaboration has recently completed the building of a PET
scanner, featuring two 10x25 cm2 planar heads at a default distance of 25 cm
from the iso-centre, that will soon be complemented by a...
S. Korpar, Ljubljana Univ.
5/3/16, 3:50 PM
Oral
We will report on the development of a novel PET scanner concept which is potentially cost-effective, could have a higher patient throughput, and would also allow for a construction of a full-body PET apparatus. The resulting detection system would provide the basis for increased sensitivity in cancer detection, providing a more robust diagnosis for an early therapy selection in an...
D. Thers, Subatech
(Subatech)
5/3/16, 4:10 PM
Oral
The goal of the innovative 3$\gamma$ medical imaging modality is to reduce significantly the dose administered to the patient. Based both on new detection technologies involving liquid xenon and on a specific 3$\gamma$ emitter radionuclide, $^{44}$Sc produced by the ARRONAX cyclotron, the 3$\gamma$ imaging has a very high potential from small animal imaging acceptances to whole body clinical...
D. Yvon, CEA-Saclay, France
(CEA-Saclay)
5/3/16, 4:30 PM
Oral
Xavier Mancardi1, Olga Kochebina1,2, Emilie Ramos1, Patrice Verrecchia1, Gérard Tauzin1, Viatcheslav Sharyy1, Clotilde Canot1 and Dominique Yvon1,*
1 CEA-Saclay, IRFU, Bat. 141, PC 20, F-91191 Gif sur Yvette Cedex (France)
2 IMIV-SHFJ-CEA, 4 place du General Leclerc 91401 Orsay Cedex (France)
* Corresponding author and proposed speaker.
Positron emission tomography (PET) is a powerful...
O. Kochebina, CEA-Saclay, France
(CEA)
5/3/16, 4:50 PM
Oral
Positron emission tomography (PET) is a powerful molecular imaging method that plays an increasing role in personalized medicine. Brain PET is especially useful for investigating the molecular dysfunctions associated with neurodegenerative diseases (ND). It contributes to the diagnosis of ND and to the monitoring of the functional changes over the course of ND. For such studies it is important...
S. Tavernier, Vrije Universiteit Brussel (BE)
(Vrije Universiteit Brussel (BE))
5/3/16, 5:10 PM
Oral
We have developed a 64 channel ASIC for reading out thousands of SiPM channels for PET applications.
A readout electronics based on this ASIC will be described, and we will present the performance of the readout in a test PET scanner setup with 2'048 channels. We will also present a comparison of the performance of our ASIC with SiPMs form different manufacturers
First results with a new...
C. Levin, Stanford, USA
5/3/16, 5:30 PM
W.W. Moses, LBNL, Berkeley, USA
5/4/16, 8:30 AM
P. Lecoq, CERN
(Lecoq)
5/4/16, 9:00 AM
Oral
Results achieved by European researchers in recent years make it likely that the 100 ps TOFPET resolution barrier can be broken. Research to reach the 10ps limit is already supported by EU funded projects (ERC Advanced grant #338953 to one member of the consortium, COST action FAST #TD1401). On the same line another member of the consortium has been recently awarded an ERC Advanced grant to...
Prof.
C. Tsoumpas, University of Leeds
(University of Leeds)
5/4/16, 9:30 AM
Oral
Scintillator-based detectors have been very successful in high energy physics (HEP) calorimetry, medical imaging, and many other applications. In particular, the potential of such detectors to achieve precise timing information is of increasing importance for those applications. Already today, scintillator-based detectors coupled to high bandwidth amplifiers are capable of producing a timing...
S. Gundacker, CERN
5/4/16, 10:20 AM
R. Martinez Turtos, Universita Milano-Bicocca & INFN, (IT)
(Universita & INFN, Milano-Bicocca (IT))
5/4/16, 10:40 AM
Oral
Scintillating crystals performance in terms of light output and timing are key parameters in order to achieve ultimate time resolution in radiation detector systems, particularly in the low energy regime of medical imaging. State-of-the-art Time of Flight measurements present Coincidence Time Resolution (CTR) values on the order of 140 picoseconds for 20 mm long LYSO:Ca crystals using 511 keV,...
D. Sánchez, Univ. Barcelona
5/4/16, 11:00 AM
Oral
Medical imaging devices have historically been based on scintillator crystals coupled to photomultipliers tubes, PMTs. The problems to combine PMTs with high electromagnetic fields and the relatively high cost per unit surface, opens new opportunities on the field for a different type of photodetector named silicon photomultiplier.
SiPM or Multipixel Photon Counter,...
Riccardo Faccini UNKNOWN
(Universita\)
Personalized/Precision medicine: Imaging technologies
Oral
INTRODUCTION: Radio-guided surgery(RGS) is a technique that helps the surgeon to perform a complete lesion resection. Currently, RGS uses γ emitting tracers, to mark the cancerous tissue form the healthy organs, and a γ radiation detection probe. To overcome the limitations due to the high penetration of γ radiation, a novel approach based on β- radiation has been developed(Camillocci, Sci...
Prof.
Osman Ratib
(University Hospital of Geneva)
Oral
The development of new techniques combining molecular imaging with targeted therapies contributed to the emergence of the concept of "theranostics" in clinical applications. Such an approach used for example in the diagnosis and treatment of neuroendocrine tumors with a molecule (or edotreotide DOTATOC) allows to specifically label the tumor cells for imaging by labeling 68Ga followed by...
