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The development of pulse tube cryocoolers (PTCs) at Shanghai Institute of Technical Physics, Chinese Academy of Sciences (SITP, CAS) is presented. These PTCs can provide cooling power from mW to tens of watts over a range of temperatures from 20 K to 170 K, which can be used to cool varieties of detectors in space applications, such as quantum interference device, radiometer, ocean color sensor and so on, because these detectors have to work at a specific temperature in order to increase signal to noise ratio (SNR), sensitivity and optical resolution. SITP has delivered many of the space-borne cooler systems and has many long life pulse tube and Stirling coolers on orbit. This paper reviews the development of the single-stage PTCs over a range of weights from 1.5kg to 10kg, and presents the results of a two-stage PTC development program.