We consider the lattice formulation of the SO(10) chiral gauge theory with left-handed Weyl fermions in the sixteen dimensional spinor representation (16)/the Standard Model in the framework of the Overlap fermion/the Ginsparg-Wilson relation. We define a manifestly gauge-invariant path-integral measure for the left-handed Weyl field using all the components of the Dirac field, but the right-handed part of which is just saturated completely by inserting a suitable product of the SO(10)-invariant 't Hooft vertices in terms of the right-handed field. We also discuss the relations of our formulation to other approaches/proposals to decouple the species-doubling/mirror degrees of freedom. Those include Eichten-Preskill model, Ginsparg-Wilson Mirror-fermion model, Domain wall fermion model with the boundary Eichten-Preskill term, and 4D Topological Insulator/Superconductor with gapped boundary phase. We clarify the similarity and the difference in technical detail and show that our proposal is a well-defined and unified testing ground for that basic question.