ICTR-PHE 2014

Feb 10, 2014, 12:00 PM → Feb 14, 2014, 4:30 PM Europe/Zurich

Centre International de Conferences de Geneve (CICG)

Jacques BERNIER, Manjit Dosanjh

A conference that brings together the International Conference on Translational Research in Radio-Oncology and Physics for Health in Europe.




Journalists can check the accreditation procedure

Please check the ICTR-PHE 2014 main website for more information on the conference itself (venue, committees, sponsorship)

Mon, February 10

12:00 PM → 1:00 PM Lunch

1:00 PM → 1:30 PM Welcome addresses

Speakers: Jacques Bernier, Manjit Dosanjh, Representative of the Geneva state, Rolf Heuer

1:30 PM → 2:00 PM The Higgs boson and our life

Conveners: Jacques Bernier, Rolf-Dieter Heuer

1:30 PM The Higgs boson and our life

Speaker: Fabiola Gianotti

Slides 01_FabiolaGianotti.pdf

2:00 PM → 4:00 PM Radiobiology

Conveners: Kevin Prise, Marco Durante

2:00 PM Ion Beam Radiobiology: From the Lab to the Clinic

Speaker: Eleanor Blakely

Slides 02_EleanorBlakely.pdf

2:30 PM International Cancer Expert Corps (ICEC)

Speaker: Norman Coleman

3:00 PM New challenges for biologically adapted ion beam treatment planning: single and multi-ion approaches

Speaker: Emanuele Scifoni

Slides Scifoni-ICTR-PHE2014-OK.pdf

3:15 PM RBE and DNA damage variation along monoenergetic and modulated Bragg peaks of a 62 MeV therapeutic protons beam

Speaker: Kevin Prise

Slides 04_KevinPrise.pdf

3:30 PM Influences of aberrant mitochondrial DNA in cancer and cancer therapy

Speaker: Marike van Gisbergen

3:45 PM Hpv Status and Effect on Radiosensitivity in Head and Neck Cancer Tumor Xenografts

Speaker: Brita S Sørensen

4:00 PM → 4:30 PM Coffee

4:30 PM → 5:00 PM Radiobiology

Conveners: Kevin Prise, Marco Durante

4:30 PM Rectal cancer and fractionation sensitivity in the neo-adjuvant radiation therapy setting: a project of meta-analysis and radiobiological modeling from individual patient data in randomized and observational data-sets

Speaker: Raymond Miralbell

4:45 PM A Biomedical Research Facility at CERN based on the Low Energy Ion Ring

Speaker: Adriano Garonna

Slides 02_AdrianoGaronna.pdf

5:00 PM → 6:15 PM Nuclear Medicine

Conveners: Irene Virgolini, Ulli Koster

5:00 PM Radiochemical aspects of radionuclide therapies

Speaker: Helmut Maecke

5:30 PM ²¹²Pb-labeled mAbs targeting CEA or HER2 during α-RIT of small peritoneal carcinomatosis – Dose effect relationship?

Speaker: Jean-Pierre Pouget

5:45 PM 152/161Tb-DOTA-RM6 biodistribution studies in prostate cancer bearing SCID mice and 149Tb sources from CERN-MEDICIS

Speaker: Thierry Stora

6:00 PM A radionuclide generator of Erbium-165, an isotope for Auger Therapy

Speaker: Gregory Severin

Tue, February 11

8:30 AM → 10:00 AM Nuclear Medicine

Conveners: Thomas Beyer, Ulli Koster

8:30 AM Clinical experience with radionuclide therapies

Speaker: Irene Virgolini

9:00 AM From bench to bedside: development and early clinical results of 188Re-SSS/Lipiodol for HCC treatment

Speaker: Nicolas Lepareur

9:15 AM PIP: a compact recirculating accelerator for the production of medical isotopes

Speaker: Adina Toader

9:30 AM Gamma Probe Based on Scintillation Crystal and Silicon Photomultiplier

Speaker: Konstantin Zhukov

9:45 AM Preclinical studies and radiopharmaceutical developments with 64Cu produced by ARRONAX facility

Speaker: Mickael Bourgeois

10:00 AM → 10:30 AM Coffee Break

10:30 AM → 12:30 PM Detectors & Imaging

Conveners: Alberto Del Guerra, Denis Dauvergne

10:30 AM From CERN to PET/MR

Speaker: David Townsend

Slides 01_DavidTownsend.pdf

11:00 AM Software challenges and opportunities for multidisciplinary PET/CT and PET/MR imaging

Speaker: Dimitris Visvikis

Slides 02_DimitrisVisvikis.pdf

11:30 AM Prompt gamma imaging of proton pencil beams at clinical beam current

Speaker: Julien Smeets

11:45 AM Prediction of β+-activity distributions from PT-PET by means of a yield approach

Speaker: Stephan Helmbrecht

12:00 PM ProXY – High performance monolithic pixel tracker for proton tomography

Speaker: Piero Giubilato

12:15 PM The recent developments of the FLUKA Monte Carlo code oriented to its applications in Hadrontherapy

Speaker: Paola Sala

12:30 PM → 1:30 PM Lunch

1:30 PM → 2:15 PM Detectors & Imaging

Conveners: Alberto Del Guerra, Denis Dauvergne

1:30 PM Different detector concepts for several imaging scenarios: from hadrontherapy monitoring to clinical imaging

Speaker: Paola Solevi

1:45 PM An integrated monitoring system for the on-line assessment of particle therapy treatment accuracy

Speaker: Vincenzo Patera

Slides 02_VincenzoPatera.pdf

2:00 PM Development of Advanced Quality Assurance Instrumentation for Hadrontherapy

Speaker: David Watts

Slides 03_DavidWatts.pdf

2:15 PM → 3:45 PM New Technologies

Conveners: Anthony Lomax, Wolfgang Enghardt

2:15 PM Novel detectors for range assessment in particle therapy

Speaker: Peter Thirolf

Slides 01_PeterThirolf.pdf

2:45 PM The ELIMED (Multidisciplinary and Medical applications at the ELI-Beams) network perspectives for laser driven beam applications

Speaker: Andrea Attili

3:00 PM Harnessing laser-plasma accelerated ion beams for applications using Gabor lenses

Speaker: Christopher Hughes

3:15 PM Positron emission tomography (PET) isotope production from laser-driven proton

Speakers: John Wong, Kai Ding

3:30 PM A novel TOF-PET detector based on organic scintillators

Speaker: Pawel Moskal

3:45 PM → 4:15 PM Coffee Break

4:15 PM → 5:30 PM New Technologies

Conveners: Anthony Lomax, Wolfgang Enghardt

4:15 PM Requirements from Oncology to Imaging Technologies

Speaker: Heinz-Peter Schlemmer

4:45 PM Potential of Detection of fast Cherenkov Photons for Improved Time of Flight Positron Emission Tomography

Speaker: Stefan Brunner

5:00 PM Experimental characterization of acoustic detection and imaging for Bragg peak localization in proton therapy

Speaker: Katia Parodi

5:15 PM A new elastic image fusion model for lung deformation simulation in 4D dose calculations

Speaker: Stefan Milz

6:30 PM → 7:30 PM Physics is beautiful and useful

Speaker: Ugo Amaldi (TERA Foundation (IT))

Slides UgoAmaldi-publictalk.pdf

Video in CDS Video in CDS

8:00 PM → 8:45 PM Cocktail

Wed, February 12

8:30 AM → 9:00 AM ESTRO lecture

Convener: Jean Bourhis

8:30 AM Individualized Radiation Oncology – harnessing clinics, biology and high technology

Speaker: Michael Baumann

9:00 AM → 10:00 AM Plenary session

Conveners: Jacques Bernier, Manjit Dosanjh

9:00 AM Health implications and applications in space

Speaker: Christer Fuglesang

9:30 AM The convergence of science - the way to develop novel radiation oncology technologies for the future

Speaker: Dag Rune Olsen

10:00 AM → 10:30 AM Coffee Break

10:30 AM → 12:00 PM Plenary session

Conveners: Jacques Bernier, Manjit Dosanjh

10:30 AM Current status of Carbon Ion Radiotherapy at NIRS

Speaker: Hirohiko Tsujii

11:00 AM Radioisotopes - the "fuel" for nuclear medicine

Speaker: Ulli Koster

11:30 AM Medical applications at CERN

Speaker: Steve Myers

12:00 PM → 1:00 PM Lunch

1:00 PM → 2:15 PM New Insights into molecular mechanisms of radio-curability

Convener: Conchita Vens

1:00 PM New insights into the complexities of NHEJ and HR repair

Speaker: Simon Powell

1:25 PM Homologous recombination deficiency and radio-curability in mouse models for BRCA1/2-deficient breast cancer

Speaker: Sven Rottenberg

1:50 PM Mechanism of HR dysfunction in single dose radiotherapy

Speaker: Zvi Fuks

1:00 PM → 2:15 PM Optimizing treatment planning and delivery

Convener: Rahde Mohan

1:00 PM New insights in IGRT for prostate cancer

Speaker: Marcel Van Herk

Slides 01_MarcelVanHerk.pdf

1:25 PM Adaptive radiotherapy

Speaker: Vincent Gregoire

1:50 PM New health technologies and evidence-based medicine

Speaker: Soren Bentzen

2:15 PM → 2:45 PM Coffee Break

2:45 PM → 4:25 PM Hadrons

Conveners: Manjit Dosanjh, Norman Coleman

2:45 PM Carbon Ion Therapy: Actual and Future Strategies at HIT

Speaker: Jurgen Debus

3:10 PM Present status of CNAO

Speaker: Roberto Orecchia

3:35 PM Proton Radiation Therapy: Current Status of Clinical Trials

Speaker: Thomas Delaney

Slides 03_ThomasDeLaney.pdf

4:00 PM France HADRON: national infrastructure for hadrontherapy research including ETOILE, ARCHADE and protontherapy centers

Speaker: Jacques Balosso

Slides 04_JacquesBalosso.pdf

2:45 PM → 4:25 PM Proffered papers - Physics I

Conveners: David Townsend, Thomas Beyer

2:45 PM The development of a low energy facility for clinical trials of Boron Neutron Capture Therapy

Speaker: Rob Edgecock

2:55 PM Interstitial Detectors for Synchronized Radiation Quality

Speaker: Giulio Magrin

Slides 02_GulioMagrin.pdf

3:05 PM An innovative on-line beam-monitoring detector based on the emission of secondary electrons

Speaker: Saverio Braccini

3:15 PM Radiotherapy Dose Monitoring to Low-Dose Morphologic Imaging with Scanned Megavoltage X-rays

Speaker: Paulo Crespo

3:25 PM Data models for the Compton camera acquisition and their influence on the reconstructed images

Speaker: Voichita Maxim

Slides 05_VoichitaMaxim.pdf

3:35 PM Detection of ionizing radiation by intrinsic optical fiber sensors: preliminary results

Speaker: Laura Cella

Slides 06_LauraCella.pdf

3:45 PM First investigations of Ultra-Thin 3D silicon detectors as microdosimeters

Speaker: Celeste Fleta

3:55 PM Frequency difference electrical impedance tomography for imaging lung tumour

Speaker: Chuan Li Yang

4:05 PM A novel dual-modality optical tomography and x-ray system for small animal radiation research platform

Speaker: Ken Kang Hsin Wang

4:15 PM Digital Image Processing Techniques for Application in a Microbeam End-Station Microscopy

Speaker: Antonios Georgantzoglou

4:30 PM → 6:00 PM Proffered papers - Biology I

Conveners: Bleddyn Jones, Kevin Prise

4:30 PM DCE-MRI and DCE-US quantification in CWR22 prostate tumour xenografts

Speaker: Natalia Arteaga-Marrero

4:40 PM Antitumor activity of combination therapy with TH-302 and irradiation in a rat rhabdomyosarcoma model

Speaker: Sarah Peeters

4:50 PM Development of a novel ELISA for detecting inducible Hsp70 in serum

Speaker: Stephanie Ertl

5:00 PM Advancing the small animal radiation research platform for pre-clinical radiation research

Speaker: John Wong

5:10 PM Evaluation of Late Toxicity Risk for RT Patients through Geant 4 Simulation of X-Ray Dose Deposition

Speaker: Frederic Brochu

5:20 PM Log file based dose calculations as a quality assurance tool in scanned beam proton radiotherapy

Speaker: Gabriel Meier

5:30 PM A Novel Radioguided Surgery Technique Exploiting - decays

Speaker: Riccardo Faccini

5:40 PM Investigation of irregular motion influence for future 4D In-beam PET imaging

Speaker: Yuan Tian

5:50 PM Ongoing investigations on ion-based radiography and tomography

Speaker: Lorena Magallanes

4:30 PM → 6:10 PM Proffered papers - Physics II (Hadrons)

Conveners: Guido Baroni, Katia Parodi

4:30 PM Initial Qualification of the Irradiation Uncertainties in Ion Beam Therapy of Prostate Cancer

Speaker: Antoni Rucinski

4:40 PM Can particle beam therapy be improved using helium ions? - A treatment planning study focusing on pediatric patients

Speaker: Barbara Knaeusl

4:50 PM MCTP: a new Monte Carlo-based treatment planning tool for hadrontherapy

Speaker: Giusseppe Battistoni

Slides 03_GiusseppeBattistoni.pdf

5:00 PM PlanIt: Planning Ion therapy open platform for treatment plans testing and comparing

Speaker: Faiza Bourhaleb

5:10 PM Robustness of range prediction in proton therapy using prompt gamma emission

Speaker: Fiere Janssen

5:20 PM Simulation of Hadrontherapy In-beam monitoring at CNAO with the INSIDE detector

Speaker: Piergiorgio Cerello

Slides 06PieriorgioCerello.pdf

5:30 PM Evaluation of existing ripple filter designs for clinical use at the MedAustron ion beam therapy facility

Speaker: Loic Grevillot

5:40 PM The (non-) detectability of failures in motion mitigated ion beam delivery by means of in-beam PET

Speaker: Kristin Stützer

5:50 PM Assessment and improvements of Geant4 models in the context of prompt-gamma hadrontherapy monitoring

Speaker: George Dedes

6:00 PM Monte Carlo modelling of whole-body secondary cancer risk for conventional and emergent radiotherapy

Speaker: Richard Hugtenburg

7:00 PM → 10:00 PM Gala Dinner

Thu, February 13

8:15 AM → 8:50 AM GH Fletcher Lecture

Convener: Ritsuko Komaki

8:15 AM Host and Tumor Immunity: Local and Systemic Opportunities to Enhance Tumor Curability by Radiotherapy

Speaker: Ralph Weichselbaum

8:50 AM → 10:05 AM From new therapeutic targets to personalized treatment

Convener: Søren Bentzen

8:50 AM Identification of new therapeutic targets

Speaker: Conchita Vens

9:15 AM Single-dose radiotherapy: from learning curve to long-term clinical outcome

Speaker: Carlo Greco

9:40 AM From bench to bedside: experience of the glioblastoma model for the optimization of radiosensitization

Speaker: Elizabeth Moyal

8:50 AM → 10:05 AM Radiotherapy - Hypoxic modification of radiotherapy

Convener: Marianne Nordsmark

8:50 AM Hypoxia-induced gene expression

Speaker: Marianne Koritzinsky

9:15 AM Impact of tumor autophagy on solid tumors response to IR: role of the tumor stroma

Speaker: Eric Deutsch

9:40 AM Hypoxia: where to go from here?

Speaker: Jens Overgaard

10:05 AM → 10:30 AM Coffee Break

10:30 AM → 11:50 AM EORTC symposium

Conveners: Philippe Maingon, Sofia Rivera

10:30 AM The new business model of the EORTC

Speaker: Emad Shash

10:50 AM The Radiation Oncology Group of the EORTC: from the past to the future

Speaker: Philippe Maingon

11:10 AM The new drug and radiotherapy working party

Speaker: Conchita Vens

11:30 AM An example of the integrated model: the EORTC DAHANCA-1219 trial

Speaker: Vincent Gregoire

10:30 AM → 11:50 AM Proffered papers - Biology II

Conveners: Raj Jena, Wolfgang Dörr

10:30 AM Enhanced RBE of sub-micrometer focused low-LET protons

Speaker: Thomas Schmid

10:40 AM Expression of common or species specific DNA damage-repair pathway related genes in thymus of low-dose-rate irradiated AKR/J and ICR mice

Speaker: Hee Sun Kim

10:50 AM [18F] HX4 PET imaging of tumour hypoxia in HNSCC patients

Speaker: Karen Zegers

11:00 AM Inhibition of tumour growth using the small molecule Cathepsin L inhibitor, KGP94

Speaker: Thomas Wittenborn

11:10 AM Delayed and Persistent Response of Human Mitochondria after Single Exposure to 0.5 to 4 Gy of Gamma Radiation

Speaker: Winnie Kam

11:20 AM Dosimetric considerations to determine the optimal technique for localized prostate cancer

Speaker: Peter Kuess

Slides 06_PeterKuess.pdf

11:30 AM Auger electron emitters labeled to monoclonal antibodies trigger cell membrane-mediated bystander effects

Speaker: Jean-Pierre Pouget

11:40 AM Comparing Ion Computed Tomography under clinical constraints

Speaker: David Hansen

10:30 AM → 11:50 AM Proffered papers - Physics III

Conveners: Denis Dauvergne, Ken Peach

10:30 AM Ultimate Time Resolution in Time-of-Flight PET

Speaker: Paul Lecoq

10:40 AM Ultrafast PET Detectors Based on Digital SiPMs and Their Use in In-Situ PET and Prompt Gamma Ray Imaging

Speaker: Dennis Schaart

Slides 02_DennisSchaart.pdf

10:50 AM 4D Dose calculations and 4D PET image reconstruction using deformable tetrahedral models of moving organs

Speaker: Petre Manescu

11:00 AM Motion compensated reconstructions in PET-based ion beam treatment verification for moving target

Speaker: Chiara Gianoli

11:10 AM Usage of long axial crystals for PET applications: the AX-PET demonstrator and beyond

Speaker: Chiara Casella

Slides 05_ChiaraCasella.pdf

11:20 AM Realistic on-the-fly dose calculation for low energy X-rays Intra-Operative Radiation Therapy

Speaker: Marie Vidal

11:30 AM A single device for mechanical and radiation Quality Assurance measurements of medical accelerators

Speakers: Ernesto Valverde, John Wong

11:40 AM A combined electrical impedance tomography and cone beam CT for radiation therapy monitoring

Speaker: Manuchehr Soleimani

11:50 AM → 12:30 PM Proffered papers - Biology III

Conveners: Raj Jena, Wolfgang Dörr

11:50 AM Oxygen ions achieve better tumour control probability in hypoxic tumours than carbon ions do

Speaker: Niels Bassler

12:00 PM Direct evaluation of ion beam radiobiological parameters from clinical data: an alternative approach to the RBE

Speaker: Andrea Attili

12:10 PM Equivalent uniform dose (EUD) based biological optimization for carbon ion therapy

Speaker: Sarah Brüningk

Slides 03_SarahBrüningk.pdf

12:20 PM Variance Based Sensitivity Analysis of Biological Uncertainties in Carbon Ion Therapy

Speaker: Florian Kamp

Slides 04_FlorianKamp.pdf

11:50 AM → 12:30 PM Proffered papers - Physics IV (Hadrons)

Convener: Sandro Rossi

11:50 AM TOF-PET scanner configurations for quality assurance in proton therapy: a patient case study

Speaker: Peter Dendooven

Slides 01_Dendooven.pdf

12:00 PM Implementation of a GPU Monte Carlo protons transport code for dose calculations: methods and challenges

Speaker: Daniel Maneval

Slides 02_DanielManeval.pdf

12:10 PM Fast pencil beam dose calculation for hadron therapy on GPU

Speaker: Joakim Da Silva

12:20 PM Parameterization of lateral dose profiles for proton therapy application at CNAO

Speaker: Martina Mori

11:50 AM → 12:30 PM Profferred papers - Radiotherapy I

Convener: Marcel Verheij

11:50 AM Modelling acute urinary toxicity after radiotherapy for prostate cancer

Speakers: Tiziana Rancati, Viviana Caillo

12:00 PM Mediators associated to the inflammatory response in prostate cancer patients undergoing RT: preliminary results

Speaker: Bedini Nice

12:10 PM Daily variation in rectal size and position during prostate radiotherapy measured from helical tomotherapy CT scans

Speaker: Jessica Scaife

12:20 PM Clinical experience with adaptive radiotherapy for muscle invasive bladder cancer

Speaker: Anne Vestergaard

Slides Vestergaard_ICTR2014.pdf

12:30 PM → 1:30 PM Lunch

1:30 PM → 2:00 PM ESO Session - E. van der Schueren Award

Convener: Alberto Costa

1:30 PM The ART of translation

Speaker: Marcel Verheij

2:00 PM → 3:15 PM Symposium in honour of Prof. Kian K. Ang- Translational research: the example of head and neck cancer

Convener: Ritsuko Komaki

2:00 PM Eulogy of Professor Kian K. Ang

Speaker: James Cox

Slides 01_JamesCox.pdf

2:25 PM Milestones of Pr Kian Ang’s scientific contribution

Speaker: Jacques Bernier

2:50 PM Molecular biology of head and neck carcinomas: old challenges, new insights

Speaker: Kevin Harrington

3:15 PM → 3:45 PM Coffee Break

3:45 PM → 4:35 PM Proffered papers - Biology IV

Conveners: Kevin McMullen, Manjit Dosanjh

3:45 PM Vimentin (EMT Marker Protein) Score As One of Predictors Resistance to Erlotinib and Radiotherapy for Patients with Stage III Non-Small Cell Lung Cancer on A Prospective Phase II Trial

Speaker: Ritsuko Komaki

Slides 01_RitsukoKomaki.pdf

3:55 PM Towards simpler and better prediction of relative biological effect (RBE)

Speaker: Bleddyn Jones

4:05 PM Combined Radiochemotherapeutical Strategies for Microtubule Stabilizing Agent (MSA)-Resistant Tumors

Speaker: Angela Broggini-Tenzer

4:15 PM Preclinical Assessment of Efficacy of Radiation Dose Redistribution Based on Intratumoral FDG-PET Uptake

Speaker: Ludwig Dubois

Slides 04_LudwigDubois.pdf

4:25 PM Fat percentage and hand grip strength in lung cancer: the influence on survival and toxicity

Speaker: Kim Smits

Slides 05_KimSmits.pdf

3:45 PM → 4:35 PM Proffered papers - Physics V (Detectors)

Conveners: Paul Lecoq, Ulli Köster

3:45 PM Verification of dynamictrajectory radiotherapy based on Monte Carlo

Speaker: Michael Fix

3:55 PM Development of a transparent photon detector for the online monitoring of IMRT beams

Speaker: Rachel Delorme

Slides 02_RachelDelorme.pdf

4:05 PM An Intensity Modulated Radiotherapy Beam Monitoring System using a Monolithic Active Pixel Sensor

Speaker: Johannes Velthuis

4:15 PM Geant4 simulation of a dedicated beam line at the CNAO facility for the study of uveal melanomas

Speaker: Edoardo Farina

Slides 04_EdoardoFarina.pdf

4:25 PM EndoTOFPET-US: A multimodal ultrasound and time of flight PET endoscope for developing new biomarkers for the prostate and pancreatic cancers

Speaker: Etiennette Auffray

3:45 PM → 4:35 PM Proffered papers - Radiotherapy II

Convener: David Brizel

3:45 PM The REQUITE project: validating predictive models and biomarkers of radiotherapy toxicity to reduce side-effects

Speaker: Tiziana Rancati

Slides 01_TizianaRancati.pdf

3:55 PM Potentiation of radiation response by a novel EGFR/DNA targeting molecule in a triple negative breast cancer model

Speaker: Beatrice Fournier

4:05 PM Studying inter- and intrafraction motion mitigation with sequential 4D CTs of lung tumor patients

Speaker: Romain Brevet

Slides 03_RomainBrevet.pdf

4:15 PM Time resolved portal dosimetry for Volumetric Modulated Arc Therapy (VMAT) in lung cancer patients with atelectasis

Speaker: Mark Podesta

4:25 PM Spot-scanning Proton Therapy for Pediatric Parameningeal Rhabdomyosarcomas: Clinical Outcome of 39 Patients Treated at PSI

Speaker: Carmen Ares

4:45 PM → 7:00 PM CERN visit

7:00 PM → 8:00 PM Cocktail in Globe

Fri, February 14

8:30 AM → 9:45 AM Panel discussion - Clinical trials in particle therapy

Conveners: Manjit Dosanjh, Vikram Bhadrasain

slides JamesCox.pdf

8:30 AM Panel discussion

Speakers: Hirohiko Tsujii, James Cox, Jürgen Debus, Roberto Orecchia

8:30 AM → 9:45 AM Radiosensitivity modulation - new angles of attack

Convener: Richard Kolesnick

8:30 AM Growth factor and integrin receptor targeting - there is more to it than just inhibition

Speaker: Nils Cordes

8:55 AM Notch and radiotherapy: does it matter?

Speaker: Marc Vooijs

9:20 AM Head-and-neck cancers: towards new, intriguing fractionation schedules

Speaker: Jean Bourhis

9:45 AM → 10:15 AM Coffee Break

10:15 AM → 11:45 AM Proffered papers - Biology V

Conveners: Tim Maughan, Vikram Bhadrasain

10:15 AM Radiosensitization of Non–Small Cell Lung Cancers by Targeting Ionizing Radiation-Induced Activation of ADAM17

Speaker: Martin Pruschy

10:30 AM Do physiological relevant doses of biguanides have any role in cancer treatment?

Speaker: Morten Busk

10:45 AM Oral mucosal radiation response (mouse) - relevance of ceramide-induced apoptosis?

Speaker: Wolfgang Dörr

11:00 AM A phase I/II study of proton and hyperthermia in primary unresectable and recurrent adult soft tissue sarcoma

Speaker: Niloy Datta

Slides 04_NiloyDatta.pdf

10:15 AM → 11:35 AM Proffered papers - Biology VI

Conveners: Kevin Prise, Norman Coleman

10:15 AM Radiobiological Considerations for Retreatment of Central Nervous System Tumours

Speaker: Bleddyn Jones

10:25 AM Gadolinium based nanoparticles for radiosensitization of head and neck squamous cell carcinoma

Speaker: Lucie Sancey

10:35 AM Noninvasive Imaging of Radiation-Induced Lung Inflammation with Positron Emission Tomography (PET) in a Murine Model

Speakers: Jin Zhang, Ken Kang Hsin Wang

10:45 AM The use of ‘planned overshoot’ for reducing dose to healthy tissue and improve treatments robustness for scanned proton beams

Speaker: Francesca Albertini

Slides 04_FrancescaAlbertini.pdf

10:55 AM Clinical testing of an in-room imaging system for patient setup verification in particle therapy

Speaker: Guido Baroni

11:05 AM Reduced side effects by proton microchannel radiotherapy – study in a human skin model

Speaker: Stefanie Girst

Slides Girst_ICTR-PHE_2014_pub.pdf

11:15 AM Entervision Wp4. Biological Dosimetric Phantom. Proof Of Concept Preliminary Results

Speaker: Thiago Viana Miranda Lima

11:25 AM A knowledge exchange case study: computational radiotherapy at Cambridge

Speaker: Michael Simmons

10:15 AM → 11:45 AM Proffered papers - Physics VI (Hadrons)

Conveners: Hirohiko Tsujii, Ugo Amaldi

10:15 AM Intra-fraction tumor tracking based on a surrogate-driven 4D CT motion model in particle radiation therapy

Speaker: Guido Baroni

10:25 AM Prompt Gamma Imaging at MGH with LaBr3 Scintillating Crystals

Speaker: Joao Seco

10:35 AM Nanoparticles and protontherapy: disentangling possible physical effects

Speaker: Yolanda Prezado

10:45 AM 95 MeV/A carbon fragmentation studies for hadrontherapy: measurements and comparisons with GEANT4 simulations

Speaker: Marc Labalme

10:55 AM Properties of therapeutic He, Li and O beams studied with Geant4

Speaker: Lucas Burigo

11:05 AM Automatic beam dose profiler for scanned pencil beams (protons and carbon ions) at the CNAO hadrontherapy facility

Speaker: Aurora Tamborini

11:15 AM Proton Interaction Vertex Imaging for carbon therapy quality control

Speaker: Regina Rescigno

11:25 AM Dual energy CT to reduce range uncertainties in hadrontherapy

Speaker: Guillaume Landry

11:35 AM Research and development of a TOF-based multi-slit collimated camera for online hadrontherapy monitoring

Speaker: Marco Pinto

11:45 AM → 12:45 PM Lunch

12:45 PM → 2:00 PM Symposium - Hadrons

Convener: Roberto Orecchia

12:45 PM Evolution of technology to optimize the delivery of proton therapy: the third generation

Speaker: Thomas Bortfeld

1:10 PM Robust optimization of IMPT dose distributions

Speaker: Radhe Mohan

Slides 02_RadheMohan.pdf

1:35 PM Proton clinical correlates of patient throughput and cyclotron availability

Speaker: Kevin McMullen

Slides 03_KevinMcMullen.pdf

12:45 PM → 2:00 PM Symposium - Imaging

Convener: Philippe Lambin

12:45 PM Hypoxia Imaging

Speaker: Marianne Nordsmark

1:10 PM Functional image-based target definition

Speaker: Robert Jeraj

Slides 02_RobertJeraj.pdf

1:35 PM Predictive and prognostic role of functional imaging of head and neck squamous cell carcinomas

Speaker: David Brizel

12:45 PM → 2:00 PM Symposium - Tumor vascularization

Convener: Jens Overgaard

12:45 PM Hypoxia modification in experimental tumours

Speaker: Daniel Zips

1:10 PM The vascular supply and microenvironment of tumours and their significance for cancer therapy

Speaker: Michael Horsman

1:35 PM Targeting hypoxia through autophagy

Speaker: Kasper Rouschop

2:00 PM → 3:15 PM Symposium - Biomarker driven individualization of radiotherapy - from preclinical validation to clinical trials?

Convener: Michael Baumann

2:00 PM Biomarker for stratification in radiotherapy - preclinical and early clinical models

Speaker: Mechthild Krause

2:25 PM Imaging for prescription function

Speaker: Daniela Thorwarth

2:50 PM How will we develop the evidence base for biologically individualized radiotherapy?

Speaker: Tim Maughan

2:00 PM → 3:20 PM Symposium - Modulation of tumor and normal tissue response to radiation

Convener: Simon Powell

2:00 PM Carbonic Anhydrase IX inhibitors: a new class of targeted agents

Speaker: Philippe Lambin

Slides 01_PhilippeLambin.pdf

2:20 PM Immunosensitization by radiotherapy: the example of immunocytokines

Speaker: Ludwig Dubois

2:40 PM Novel strategies to spare normal tissues from radiation damage

Speaker: Marie-Catherine Vozenin

3:00 PM Intestinal Stem Cells are Radiation Resistant

Speaker: Richard Kolesnick

3:20 PM → 3:40 PM Concluding remarks

Speakers: Jacques Bernier, Manjit Dosanjh (CERN)