Speaker
Description
Over the last few years, several studies have proven the effect of targeted alpha therapy using Ac-225 and Bi-213 [1, 2, 3]. One of the crucial bottlenecks in upscaling these studies and moving to clinical trials is the availability of these isotopes. The current production methods cannot provide sufficient quantities of Ac-225 or its daughter Bi-213. Furthermore, some of these production techniques result in batches of Ac-225 with a lot of impurities which require advanced radiochemical separation techniques to be purified, and with limited specific activity (e.g. contamination from Ac-227). Therefore, the ISOL-technique is under investigation as a new production route for these isotopes, as it could provide both chemical and isotopic separation, to reach high purity and high specific activity. Recently, the first online radioactive Ac+ beams at CERN-ISOLDE have been produced with the Resonant Ionization Laser Ion Source (RILIS) [4]. Full characterization of the Ac+ beam has been performed.
Recent results on the beam production of Ac isotopes will be presented, focusing on Ac-225 and Bi-213 as medical radioisotopes. These measurements can be extrapolated to the CERN-MEDICIS facility as an indication of the batches that can be collected for medical research in the near future.
References
[1] M. Sathekge et al. 225Ac-psma-617 in chemotherapy-naive patients with advanced prostate cancer: a pilot study. European Journal of Nuclear Medicine and Molecular Imaging, Sep 2018.
[2] L. Finn et al. A phase 2 study of actinium-225 ( 225Ac)-lintuzumab in older patients with previously untreated acute myeloid leukemia (aml) unfit for intensive chemotherapy. Blood, 130(Suppl 1):2638–2638, 2017.
[3] L. Krolicki et al. Prolonged survival in secondary glioblastoma following local injection of targeted alpha therapy with 213Bi-substance p analogue. European Journal of Nuclear Medicine and Molecular Imaging, 45(9):1636–1644, Jul 2018.
[4] V.N. Fedosseev et al. Ion beam production and study of radioactive isotopes with the laser ion source at ISOLDE. Journal of Physics G 44:084006, July 2017.
