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The isotope of 186Re is widely used (glass-based TheraSphere, Nordion, Canada and resin-based SIR-Spheres, Australia) for transarterial radioembolism in hepatocellular carcinoma (second in the world in total mortality).
The average -radiation energy of 186Re 1.07 MeV is one of the highest among the radionuclides used in palliative therapy.
The powder of rhenium activated by bremsstrahlung at the Linac of the NSC KIPT. The photonuclear reaction 187Re(,n)186Re was used. After activation, the powder was dissolved in HCl and, according to one of the methods, was homogenized with clinoptilolite particles (2040 μm), which were previously treated with hexadecyltrimethylammonium chloride to more efficiently sorption rhenium. The resulting mixture modified thermally. According to the second method, after the activated powder was dissolved in the HCl solution, electrolysis was carried out at pH=1.5, followed by isolation of 186ReО2 at the cathode in the form of clinoptilolite particles [1].
The proposed methods for obtaining the isotope 186Re can significantly reduce the cost of the procedure of radionuclide therapy in comparison with the used commercial agents.
[1.] E. Salakhova, V. Majidzade, F. Novruzova et all. The Electrodeposition of Rhenium in Alkaline and Acidic Elektrolytes // J. Chem. Chem. Eng. – 2012. – v.6 – p.489-494.
