PRODUCTION OF HIGH PURIFIED AMMONIUM SALTS FOR NUCLEAR MEDICINE AND LOW BACKGROUND APPLICATIONS

Oct 13, 2020, 6:35 PM
1h
Online

Online

Poster report Section 3. Modern nuclear physics methods and technologies. Poster session 6

Speaker

Mr Nijat Mirzayev (Joint Institute for Nuclear Research, DLNP, 141980 Dubna, Russi)

Description

Ammonium salts are at the basis for the synthesis of a number of substances, which are used in different medical applications. Ammonium media has no adverse effects on the body. It is chemically and biologically sufficiently stable. These salts often used as a buffer for binding the radionuclide to a chelator, which in turn promotes the binding of the radionuclide to the active part (peptide, antibody, etc.) of radiopharmaceuticals. It is very important to obtain radiopharmaceuticals with the highest specific activity. For this reasons, substances with a minimum content of two-, three-, and tetravalent elements are required for nuclear medicine applications.
In addition, ammonium salts are used as a fluxing agent in soldering for electronic devices that work in the area of low-background experiments (for example, neutrino physics). The solder and flux must meet the requirements of radioactive purity.
The chemical properties of impurities are usually similar to the basic substance, otherwise they would have easily separated in its synthesis. Therefore, developing combined methods of purification is very important.
In this work, we report the production process of a high purified ammonium salt. The initial components for the synthesis of salt was undergo an additional purification by sub-distillation. The synthesis of ammonium salt was achieved with transfer of gas phase ammonia to the acid. The final product obtained is a dry salt of ammonium chloride and ammonium acetate in form of white granules.
To achieve high purity of the final product all the processes were performed in a clean room (JINR, Dubna) with the use of chemically resistant equipment made from pre-purified materials.
A γ-ray screening with ultra-low background spectrometer, an instrumental neutron activation analysis and ICP-MS elemental analysis have been performed to estimate the radioactivity level and composition of the final product. Will be presented comparison results for commercial and custom-made ammonium salts.

Primary author

Mr Nijat Mirzayev (Joint Institute for Nuclear Research, DLNP, 141980 Dubna, Russi)

Co-authors

Dmitry Filosofov (a Laboratory of Nuclear Problems, JINR, Dubna, 141980, Russia) Khagani Mammadov ( Institute of Radiation Problems of Azerbaijan National Academy of Sciences, Baku, Azerbaijan) Maryvonne De Jesus ( Univ Lyon, Université Lyon 1, CNRS/IN2P3, IP2I-Lyon , F-69622, Villeurbanne, France) Dimitr Karaivanov Dmitry Ponomarev Alimardon Rakhimov Irina Rozova Sergey Rozov Nargiza Temerbulatova Zhanna Burmii Evgeny Yakushev

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