Speaker
Kristina Herfert
Description
Simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) allows the study of molecular and functional processes in the living brain and their spatial and temporal correlation. Our goal is to develop and apply protocols and methods to evaluate molecular changes in receptor and neurotransmitter concentrations by PET and hemodynamic changes by BOLD-fMRI to exploit the complementarity of both modalities for a better understanding of neurological diseases as well as for the development of new treatment strategies. To this end, we are using different rat models and genome engineering technologies targeting specific genes, proteins, and signaling pathways in the brain.
