Differentiation between neurodegenerative parkinsonisms, whose early clinical presentation is similar, may be improved with metabolic brain imaging. We identified the characteristic metabolic patterns for Parkinson's disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) – PDRP, MSARP and PSPRP – in a new European cohort.
Brain scans of a Slovenian cohort of 20...
The quality of positron emission tomography reconstructed images can be increased by improving the time-of-flight measurement, which is mainly limited by the time response of the standard scintillators (e.g., LYSO, BGO). Another possible option to develop new devices is to use Cherenkov light emitted by electrons moving with velocities exceeding the speed of light in the chosen radiator...
Background: Little progress was made during the last decades to improve the spatial resolution of brain PET scanners, even though the achieved state-of-the-art is far worse than the theoretical limit.
Aim: Develop an ultra-high-resolution (UHR) PET imager based on the field-proven LabPET-II technology platform for human brain imaging at the physical resolution limit.
Method: The...
Dense Cherenkov radiators provide an opportunity for high gamma detection efficiency - due to their high stopping power and photofraction - and excellent coincidence time resolution (CTR). However, because only a few tens of Cherenkov photons follow a gamma interaction in the radiator, the detection efficiency and the energy resolution of a pure Cherenkov detector are an issue. We study gamma...
In time-of-flight positron emission tomography (TOF-PET) excellent coincidence timing resolution (CTR) reduces angular coverage requirements of the scanner, which in turn reduces geometric constraints of the design of the PET scanner. One of the possibilities that this opens is the use of flat panel PET detectors. Such a design would allow a higher degree of modularity and be more compact and...
