As an upgrade of the asymmetric e+e− collider KEKB, SuperKEKB aims to increase the peak luminosity by a factor of 40 to 8×10^35 cm^−2s^−1. The upgraded Belle II detector allows the experiment to handle the much increased data rates, with the goal to explore new physics beyond the Standard Model at the intensity frontier. Belle II is expected to accumulate a dataset of 50 ab^−1 by 2027. The Belle II pixel detector (PXD) has been developed using the DEpleted P-channel Field Effect Transistor (DEPFET) technology, which combines low power consumption in the active pixel area and low intrinsic noise with a very small material budget. In this talk commissioning and performance of this novel detector measured with first collision data will be presented.