Speaker
Description
In this study, a novel cancer treatment with low side effect and less invasiveness by blocking newborn blood vessels around the diseased part was proposed. In the therapy, ferromagnetic particles administered into the body are accumulated in the newborn blood vessels using a rotating magnetic field, and then are aggregated by a uniform magnetic field to block the blood vessels. The blockage prevents the cancer growth and metastasis. The particles are selectively accumulated on-axix of the rotating magnetic field by the cyclic motion on the inner wall of the blood vessel since a stable magnetic force acts on the particle.
A previous study in our group showed the possibility of local accumulation of the ferromagnetic particles on the rotation axis 25 mm away from a magnetic field source by using a high-frequency rotating magnetic field. In order to put this therapy into practical use for cancers located deep in the body, it is necessary to accumulate the particles at a target site about 300 mm away from the magnetic field source. In this research, we propose an application method of the rotating magnetic field by utilizing four superconducting magnets and a cylindrical magnetic shielding material with a slit. In this method, the four superconducting magnets are excited at the same time, and the rotating magnetic field is applied by the leakage magnetic field from the slit of the rotating shielding material. Accordingly, we designed a rotating magnetic field that can locally accumulate the particles at the target site 300 mm away from the magnetic field source and examined the possibility of particle accumulation by the simulation based on magnetic field and fluid analysis and the model experiment by using simulated organ.
Acknowledgment: A part of this research was supported by Magnetic Health Science Foundation.
