REACTOR PRODUCTION OF NUCLEAR MEDICINE ALPHA‑EMITTERS WITH RADIUM-226

Oct 13, 2020, 5:00 PM
25m
Online

Online

Oral report Section 8. Nuclear medicine. Section 8. Nuclear medicine

Speaker

A.A. Lumpov (V.G. Khlopin Radium Institute, St. Petersburg 194021, Russia)

Description

Radioisotopes of 227Ac and 227,228,229Th are basis of the radiochemical generators for production of alpha-emitters radium-223, radium-224, actinium-225 and bismuth-213. These generator radionuclides are used to produce radiopharmaceuticals and therefore their radiochemical purity has to be maintained high demands. For example, actinium-225 generator has to contain less than 1·10-3 % of each Ra and Th isotopes (standard of ORNL), radium-223 generator – less than 0.5% of thorium-227 and 0.04% of actinium-227.
Irradiated radium-226 used in the presented work is contained mixture of all abovementioned isotopes with their daughter radionuclides. In frame of the presented work methods of chromatographic extraction [1] of thorium-229 and actinium-227 from irradiated radium-226 have been developed and tested with technological reprocessing procedures [2]. Activities of 226Ra, 227Ac, 227,229Th and their daughter nuclides for chemical procedures and final batches have been measured with gamma- and alpha-spectrometry. Measured activities of 227Ac and 227,229Th were compared with values calculated by a computer code.

  1. E.P. Horwitz, et al. // Solv. Extr. Ion Exch. 2005. V. 23. P. 319.
  2. B. Zieliinska et al. // Solv. Extr. Ion Exch. 2007. V. 225. P. 339.

Primary authors

A.A. Lumpov (V.G. Khlopin Radium Institute, St. Petersburg 194021, Russia) L.V. Krasnikov (V.G. Khlopin Radium Institute, St. Petersburg 194021, Russia) A.I. Kostylev (V.G. Khlopin Radium Institute, St. Petersburg 194021, Russia) Yu.I. Trifonov (V.G. Khlopin Radium Institute, St. Petersburg 194021, Russia) V.N. Dushin (V.G. Khlopin Radium Institute, St. Petersburg 194021, Russia) V.A. Jakovlev (V.G. Khlopin Radium Institute, St. Petersburg 194021, Russia) Y.Y. Petrov (V.G. Khlopin Radium Institute, St. Petersburg 194021, Russia)

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