Very High Energy Electron Radiotherapy Workshop (VHEE'2020)

Europe/Zurich
CERN

CERN

Angeles Faus-Golfe (Université Paris-Saclay (FR)), Manjit Dosanjh, Roberto Corsini (CERN)
Description

VHEE2020

Establishing innovative treatment modalities for cancer is a major 21st century health challenge. Although accelerated electrons are widely used to generate X-rays for radiotherapy, electrons are less frequently used directly because low energy electrons have limited penetration range and are  mostly for the treatment of superficial tumours and thus limiting their clinical applicability.

Recently, studies involving ultra-high dose rate (mean dose rate above 100 Gy/s) delivery of ionizing radiation, termed FLASH radiotherapy (FLASH-RT), have uncovered some unexpected but possible therapeutic benefits caused tremendous excitement in the radio-oncology fieldData appear to show that FLASH-RT affords significant normal tissue sparing without compromising tumour control.

In addition, the idea of investigating the use of very high-energy (50-250 MeV) electron (VHEE) beams for RT has gained interest, since electrons with higher energies can travel deeper into the patient. The advantages of this very high-energy electron therapy (VHEE) are that the depth – dose profile from the electrons is flatter than the quasi-exponential dose given by X-rays, and in addition – in principle – the delivered electrons (which are charged) may be focused and steered in ways that are not possible for X-rays. The challenge until recently has been the difficulty in obtaining high-energy electrons using compact machines. This can now be overcome either with high-gradient cavities or by using laser-based acceleration.

Therefore, it is highly timely to have a follow up meeting to VHEE 2017 https://www.cockcroft.ac.uk/events/VHEE17/

The list of topics to be explored are:

  • State of the Art;
  • Mechanism and Innovation for FLASH RT;
  • New indications and hot topics;
  • Facilities  description: current and planned, e.g. exploitation and use of the existing facilities CLEAR, CLARA, ELBE, PITZ;
  • Demonstrate capability of conventional RF acceleration techniques including SC for VHEE RT applications;
  • Overall VHEE compact machine design including costing;
  • Dosimetry and Detectors;
  • Treatment Planning, Modelling and Imaging;
  • Accelerators R&D and Technologies for medical treatment, e.g. novel acceleration techniques;
  • Industrial panel for medical technologies and plans;
  • Where are we going? Which experiments/facilities are needed?

The sessions will be fully remote. The video details will be communicated one week before the meeting. 

For organisational purposes, you are kindly requested to REGISTER to this event using the form on the left menu.

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CLIC Project Office
Participants
    • 15:00 16:15
      State of the Art
      Convener: Roberto Corsini (CERN)
      • 15:00
        Clinical perspectives for FLASH therapy 20m
        Speaker: Jean Bourhis (CHUV)
      • 15:25
        Novel high-gradient accelerators for radiotherapy and imaging 20m
        Speaker: Emilio Nanni (SLAC)
      • 15:50
        Dosimetry of electron beams - challenges and possible solutions for VHEE and FLASH 20m
        Speaker: Andreas Schüller (PTB)
    • 16:15 16:25
      Welcome Speech 10m
      Speaker: Roberto Corsini (CERN)
    • 16:25 16:35
      Break & Group photo 10m
    • 16:35 17:35
      Mechanism and Innovation for FLASH RT
      Convener: Manjit Dosanjh
      • 16:35
        Neuroprotective effects of FLASH-RT in the juvenile and adult brain 15m
        Speaker: Charles Limoli (University of California, Irvine)
      • 16:55
        Tumor response to FLASH-RT 15m
        Speaker: Marie-Catherine Vozenin (CHUV)
      • 17:15
        Electron dose rate and oxygen depletion protect zebrafish embryo from radiation damage 15m
        Speaker: Elke Beyreuther (Helmholtz-Zentrum Dresden - Rossendorf)
    • 17:35 17:45
      Break 10m
    • 17:45 18:45
      New indications and hot topics
      Convener: Angeles Faus-Golfe (Université Paris-Saclay (FR))
    • 18:45 18:50
      Closing 5m
    • 15:00 16:00
      Facilities description, current and planned ones (Chaired by Claude Bailat)
      Convener: Claude Bailat (CHUV)
      • 15:00
        CLEAR for Radiotherapy Research 15m
        Speaker: Wilfrid Farabolini (Université Paris-Saclay (FR))
      • 15:20
        Full energy beam exploitation possibilities on CLARA at Daresbury Laboratory 15m
        Speaker: Deepa Angal-Kalinin (STFC)
      • 15:40
        High-gradient RF systems for compact accelerators 15m
        Speaker: Walter Wuensch (CERN)
    • 16:00 16:10
      Break & Group Photo 10m
    • 16:10 17:10
      Facilities description, current and planned ones (Chaired by Charles Limoli)
      • 16:10
        New FLASH radiation therapy R&D options at PITZ 15m
        Speaker: Frank Stephan (DESY)
      • 16:30
        Radiation biology with laser-accelerated electrons at LOA 15m
        Speaker: Alessandro Flacco (ENSTA)
      • 16:50
        Novel high-gradient accelerators for radiotherapy and imaging 15m
        Speaker: Bill Loo (Stanford University)
    • 17:10 17:20
      Break 10m
    • 17:20 18:20
      Dosimetry and Detectors (Chaired by Marie-Catherine Vozenin)
      • 17:20
        Diamond-based detector development for pulsed beam monitoring for medical applications 15m
        Speaker: Marie-Laure Gallin-Martel (CNRS)
      • 17:40
        Dosimetry of particle beams with ultra-high pulse dose rates 15m
        Speaker: Anna Subiel (NPL)
      • 18:00
        The challenges of Ultra high dose rate dosimetry for preclinical irradiation 15m
        Speaker: Claude Bailat (CHUV)
    • 18:20 18:30
      Break 10m
    • 18:30 19:30
      Treatment Planning, Modelling and Imaging (Chaired by Roger Jones)
    • 19:30 19:35
      Closing 5m
    • 15:00 16:10
      Accelerators R&D and Technologies for medical (Chaired by Frank Stephan)
      • 15:00
        Compact high-energy electron accelerator at Tsinghua University 15m
        Speaker: Jiaru Shi
      • 15:20
        Sources for high dose rate electron and proton irradiation at the ELBE center Dresden 15m
        Speaker: Ulrich Schramm
      • 15:40
        Research and Development of High Efficiency, High Gradient Accelerator Systems for VHEE at SLAC 15m
        Speaker: Emma Snively (SLAC)
      • 16:00
        Experience with electron linear accelerators for low-energy FLASH Intraoperative RT with perspectives on VHEE beams 10m
        Speaker: Luigi Faillace (University di Roma)
    • 16:15 16:25
      Break 10m
    • 16:25 18:02
      Industries for medical (Chaired by Gerardo D'Auria and Sami Tantawi)
      • 16:25
        Outline of the roadmap involved in taking a working design through to something that is approved to treat clinical 5m
        Speaker: John Allen (ELEKTA)
      • 16:35
        Perspectives for industrial superconducting accelerators for isotope production and radiation therapy 5m
        Speaker: Claudio Serpico
      • 16:45
        Progress status for the 40 MeV Rhodotron and the new very high dose rate 10 MeV Flash platform at Aérial/Feerix 5m
        Speaker: Jeremy Brison (IBA)
      • 16:55
        Inverse Compton scattering X-ray source optimized for radiotherapy 5m
        Speaker: Benjamin Hornberger (Lynceantech)
      • 17:05
        Compact linac design for FLASH radiation therapy 5m
        Speaker: Arundhuti Ganguly (TiBaRay)
      • 17:15
        High Frequencry (12 GHz) RF generated electrons (100 MeV) 5m
        Speaker: Christopher Barty (Lawrence Livermore National Laboratory)
      • 17:25
        The challenge of high dose rate for ionisation chambers 10m
        Speaker: Daniela Poppinga (PTW)
      • 17:35
        Capabilites of the AWA facility for potental medical applications 7m
        Speaker: Jing Chunguang
      • 17:45
        Single electron imaging of samples using multiple coulomb scattering 7m
        Speaker: Hendrick Jansen
      • 17:55
        Plans for growth in accelerator physics in Australia: medical and VHEE applications 7m
        Speaker: Suzie Sheehy (University of Melbourne)
    • 18:05 18:15
      Break 10m
    • 18:15 19:30
      Where are we going? Which experiments/facilities are needed? (Chaired by Jean Bourhis)
      Convener: Manjit Dosanjh
      • 18:15
        Main topics 15m
        Speakers: Manjit Dosanjh, Angeles Faus-Golfe
      • 18:30
        Roundtable discussion 45m
        Speakers: Manjit Dosanjh, Angeles Faus-Golfe
      • 19:15
        Concluding remarks 15m
        Speakers: Manjit Dosanjh, Angeles Faus-Golfe