We present the first study of the color-singlet (CS) leptoproduction at QCD next-to-leading order (NLO). This process is extremely difficult. The CS hadroproduction at NLO was studied in 2007, ten years has passed since then, the study of the leptoproduction at NLO was missing until we finished this work in May, 2017. This talk will present our results, and discuss its phenomenological aspects.