2nd Annual ARDENT Workshop & ARDENT MidTerm Review

14 Oct 2013, 10:45 → 18 Oct 2013, 18:00 Europe/Zurich

Beltrami (Politecnico di Milano)

The second annual ARDENT workshop takes place at the Politecnico of Milano during the celebration of the POLIMI's 150th anniversary. The Workshop gathers together all fifteen ESRs and their supervisors to update on the progress made at each institution and exchange information.
During this workshop, each ESR presents the work done so far, experts are invited to deliver training courses on experimental micro- and nanodosimetry, and an entire day is dedicated especially to outreach activities.
The Mid-term review will also take place this week, with the participation of the EU Project Officer.

Beltrami Room map BELTRAMI.pdf

De Donato Room map OSVALDO_DE_DONATO.pdf

Monday 14 October

10:45 → 18:15 ARDENT Midterm review

10:45 Welcome & Introduction

Short introduction by the Research Executive Agency Representative and the Coordinator.

Speakers: Marco Silari (CERN), Mika Levonen

11:00 Tour de table

Each supervisor from each Institute should briefly present (5 min) their research team and describe their role within the network.

11:40 ARDENT Project Overview

A presentation by the Coordinator on the Network and the Mid-Term Review Report. The presentation cover scientific, training and networking topics.

Speaker: Marco Silari (CERN)

Slides Silari_ARDENT_Mid-Term_overview.pdf Silari_ARDENT_Mid-Term_overview.pptx

12:30 Lunch

14:00 ESR 1 presentation - CERN

Speaker: Eleni Aza (CERN)

Slides ARDENT_ESR1_Eleni.pdf ARDENT_ESR1_Eleni.pptx

14:15 ESR 2 presentation - CERN

Speaker: Erik Frojd (Mittuniversitetet (SE))

Slides ARDENT_ESR2_Erik.pdf ARDENT_ESR2_Erik.pptx

14:30 ESR 3 presentation - CERN

Speaker: Silvia Puddu (CERN)

Slides ARDENT_ESR3_Silvia.pdf ARDENT_ESR3_Silvia.pptx

14:45 ESR 4 presentation - CERN

Speaker: Stuart Patrick George (CERN)

Slides ARDENT_ESR4__Stuart_George.pdf

15:00 ESR 5 presentation - SL

Speaker: Jayasimha Bagalkote

Slides ARDENT_ESR5_Jay.pdf ARDENT_ESR5_Jay.pptx

15:15 ESR 6 presentation - AIT

Speaker: Andrej Sipaj

Slides ANDREJ_ARDENT_MEETING.pdf ANDREJ_ARDENT_MEETING.pptm

15:30 ESR 7 presentation - CTU

Speaker: Zdenek Vykydal (Czech Technical University (CZ))

Slides ARDENT_ESR7_Ivan.pdf

15:45 Coffee break

16:15 ESR 8 presentation - CTU

Speaker: Kevin Loo

Slides ARDENT_ESR8_Kevin.pdf ARDENT_ESR8_Kevin.pptx

16:30 ESR 9 presentation - CTU

Speaker: Benedikt Ludwig Bergmann (Czech Technical University (CZ))

Slides ARDENT_ESR9__Benedikt_Bergmann.pdf ARDENT_ESR9__Benedikt_Bergmann.pptx

16:45 ESR 10 presentation- IBA

Speaker: Francesca Bisello

Slides ARDENT_ESR10__Francesca_Bisello.pdf ARDENT_ESR10__Francesca_Bisello.pptx

17:00 ESR 11 presentation - IBA

Speaker: Michele Togno

Slides ARDENT_ESR11_Michele.pdf ARDENT_ESR11_Michele.pptx

17:15 ESR 12 presentation - JABLOTRON

Speaker: Dr Vijayaragavan Viswanathan

Slides ARDENT_ESR_12_Viswanathan.pdf (Protected) ARDENT_ESR_12_Viswanathan.ppt (Protected)

17:30 ESR 13 presentation - MIAM

Speaker: Alvin Sashala Naik

Slides ARDENT_ESR13_Alvin.pdf ARDENT_ESR13_Alvin.pptx

17:45 ESR 14 presentation - POLIMI

Speaker: Elena Sagia

Slides Esagia_Presentation.pdf Presentation.pptx (Protected)

18:00 ESR 15 presentation - POLIMI

Speaker: Christopher Cassell (P)

Slides

• ARDENT_ESR13_Chris.pdf
• ARDENT_ESR15_Chris.pdf
• ARDENT_ESR15_Chris.pptx

Tuesday 15 October

09:00 → 15:45 ARDENT Board Meetings

09:00 ARDENT Training Board

Speakers: Alberto Fazzi, Antonio Parravicini (M), Jan Jakubek (Czech Technical University (CZ)), Juan Carlos Celi, Pavel Hubner (Jablotron), Peter Beck (Seibersdorf Laboratories), Robert Froeschl (CERN), Sofia Rollet (AIT- Austrian Institute of Technology)

Slides Agenda_TB_15_10_2013.docx Agenda_TB_15_10_2013.pdf

10:45 ARDENT Technical Training Board

Speakers: Matteo Magistris (CERN), Sofia Rollet (AIT- Austrian Institute of Technology), Zdenek Vykydal (Czech Technical University (CZ)), marco caresana (POlitecnico di Milano)

Slides Agenda_TTB_15_10_2013.docx Agenda_TTB_15_10_2013.pdf

13:30 ARDENT Dissemination and Outreach Board

Speakers: Marcin Latocha (AIT Austrian Institute of Technology GmbH), Michael Campbell (CERN), Michael Lerch (University of Wollongong), Sofia Rollet (AIT- Austrian Institute of Technology), Dr Stanislav Pospisil (Institute of Experimental and Applied Physics, Czech Technical University in Prague), Vladimir Stanislav (Jablotron Alarms a.s.), marco caresana (POlitecnico di Milano)

Slides Agenda_DOB_15_10_2013.docx Agenda_DOB_15_10_2013.pdf

09:00 → 12:00 ARDENT Midterm review

09:00 Meeting between the Fellows and the Research Executive Agency Representative

10:15 Coffee break

12:00 → 13:30 Lunch

13:30 → 17:45 Roundtable discussion

13:30 Discussion on M5/M6 milestones

Speakers: Marco Silari (CERN), marco caresana (POlitecnico di Milano)

Slides Discussion_M5_and_M6.pdf Discussion_M5_and_M6.pptx

14:15 Rehearsal of ESR talks at the IEEE Dosimetry Workshop

15:45 Coffee break

16:15 Discussion on the organization of the course on Business and Administration and secondments to private partners

16:45 WP4 measurement campaigns

Speakers: Marco Silari (CERN), Matteo Magistris (CERN)

Slides WP4_Milan.pdf

Wednesday 16 October

09:00 → 17:30 Outreach Day “MISURARE LE RADIAZIONI: UN ASPETTO FONDAMENTALE NELLA PRATICA MEDICA, INDUSTRIALE, NELLA RICERCA E NEL PROGRESSO AEROSPAZIALE”

09:30 Benvenuto / Welcome introduction

Speakers: Marco Silari (CERN), Stefano Agosteo (Politecnico di Milano)

09:45 Il programma ARDENT della Unione Europea / The ARDENT European Union project

Speaker: Marco Silari (CERN)

Slides ARDENT_Outreach_16_October_2013.pdf ARDENT_Outreach_16_October_2013.pptx

10:30 ARDENT per tutti / Ardent for all

Speaker: Silvia Puddu (Universitaet Bern (CH))

Slides seminariMilano.pdf

11:00 Incontri con i ricercatori ARDENT e dimostrazione delle attività di ricerca / Meetings with ARDENT researchers and presentations of the scientific activities

14:30 ARDENT per tutti / Ardent for all

Speaker: Silvia Puddu (CERN)

Slides Ardent_per_tutti.pdf

15:00 Incontri con i ricercatori ARDENT e dimostrazione delle attività di ricerca / Meetings with ARDENT researchers and presentations of the scientific activities

12:00 → 13:30 Lunch

13:30 → 16:30 ARDENT Board Meetings

13:30 ITN Management Office

Speakers: Juan Carlos Celi (IBA), Marco Silari (CERN), Sofia Rollet (AIT- Austrian Institute of Technology), Vladimir Stanislav (Jablotron Alarms a.s.)

Slides Agenda_ITN_MO_15_10_2013.docx Agenda_ITN_MO_15_10_2013.pdf

15:00 ARDENT Supervisory Board

Speakers: Anatoly Rozenfeld (University of Wollongong), Anthony Waker (university of Ontario), Antonio Parravicini (M), Prof. Lawrence Pinsky (University of Houston (US)), Marco Silari (CERN), Massimo Mazzillo (STMicroelectronics), Dr Peter Beck (AIT-Seibersdorf Laboratories), Sofia Rollet (AIT- Austrian Institute of Technology), Dr Stanislav Pospisil (Institute of Experimental and Applied Physics, Czech Technical University in Prague), Stefano Agosteo (Politecnico di Milano), Stuart Patrick George, Thilo Michel (University of Erlangen), Uwe Mollenhauer (IBA), Valeria Conte (INFN Legnaro National Laboratories), Vladimir Stanislav (Jablotron Alarms a.s.)

Slides Agenda_SB_16_10_2013.docx Agenda_SB_16_10_2013.pdf

Thursday 17 October

09:00 → 18:30 Training Courses on Experimental Micro- and Nano-dosimetry

09:00 Introductory lecture on microdosimetry

1. The energy transfer points 2. The single-event energy imparted 3. Single-event microdosimetric quantities 4. Multi-event microdosimetric quantities 5. Micro and macro dosimetry 6. From micro-to-macro dosimetry for low and high LET radiations.

Speaker: Dr Paolo Colautti

Slides Colautti_Introductory_Lecture_on_Microdosimetry.pdf Colautti_Introductory_Lecture_on_Microdosimetry.pptx

10:00 Gas detectors for microdosimetry

FUNDAMENTALS • Gas ionization • Charge collection • Cavity chambers GAS DETECTORS for MICRODOSIMETRY • Ionization Chambers o Variance method o Recombination Chambers • Proportional Counters o Principles of Operation o Tissue Equivalent Proportional Counters (TEPC) o TEPC Properties and Applications o Multi-element TEPCs o Heterogeneous Counters o Wall-Less Counters FUTURE NEEDS and CHALLENGES • Size and sensitivity • Neutron-Charge particle discrimination • Calibration • Signal Processing

Speaker: Dr Anthony Waker

Slides Waker_Gas_Detectors_for_Microdosimetry.pdf Waker_Gas_Detectors_for_Microdosimetry.pptx

11:00 Coffee break

11:30 Quality assessment of hadrontherapy fields with TEPCs

1. Mini TEPC design and construction 2. Vacuum and gas flow 3. The electronic chain 4. Mini TEPC energy calibration 5. Data processing 6. Therapeutic proton-beam qualities 7. BNCT radiation-field qualities

Speaker: Dr Paolo Colautti (LNL INFN)

Slides Colautti_Quality_assessment_of_hadrontherapy_fields_with_TEPCs.pdf Colautti_Quality_assessment_of_hadrontherapy_fields_with_TEPCs.pptx

12:30 Lunch

14:00 Principle of Silicon based microdosimetry

Silicon detectors are being studied as microdosimeters since they can provide sensitive volumes of micrometric dimensions. They can be applied for assessing single event effects in electronic instrumentation exposed to complex fields around high-energy accelerators or in space missions. When coupled to tissue-equivalent converters, they can be used for measuring the quality of radiation therapy beams or for dosimetry. The use of micrometric volumes avoids the contribution of wall effects to the measured spectra. Further advantages of such detectors are their compactness, cheapness, transportability and a low sensitivity to vibrations. Anyway, the following problems should be solved when a silicon device for microdosimetry: i) the sensitive volume has to be confined in a region of well-known dimensions; ii) the electric noise limits the minimum detectable energy; iii) corrections for tissue-equivalency should be made; iv) corrections for shape equivalency should be made when referring to a spherical simulated site of tissue; v) the angular response should be evaluated carefully; vi) the efficiency of a single detector of micrometric dimensions is very poor and detector arrays should be considered. Several devices are being proposed as silicon microdosimeters, based on different technologies (telescope detectors, silicon on insulator detectors and arrays of cylindrical p-n junctions with internal amplifications), in order to satisfy the issues mentioned above.

Speakers: Andrea Pola (Politecnico di Milano), Stefano Agosteo (Politecnico di Milano)

Slides Agosteo_Pola_Principle_of_silicon-based_microdosimetry.ppt.pdf Agosteo_Pola_Principle_of_silicon-based_microdosimetry.ppt.pptx

15:00 Silicon microdosimetry

1. Introduction to Solid State microdosimetry 2. Electronic , calibration and sensitivity of Si microdosimeter 2.1. Comparison of TEPC to Si-microdosimeter 3. Concept and design of Silicon on Insulator (SOI) microdosimeters 3.1. Three generation of SOI microdosimeters 3.2.Charge collection in Sensitive Volumes (SV) of SOI microdosimeters 4.Application of SOI microdosimeters 4.1.Radiation protection (Cf-252 and Pu-Be Sources) 4.2.Hadron Therapy 4.2.1.Fast Neutron Therapy (FNT) 4.2.2.Proton Therapy (PT) 4.2.3.Heavy Ion Therapy.(HIT) 4.2.4. LEM vs MKM –SOI microdosimetry experience 5. 3D detector technology-future of Si microdosimetry. 5.1.Pecularities of charge collection in 3D Si detectors 5.2.Concept and design of 3D Si microdosimeter. 5.3.GEANT 4 modeling of 3D microdosimeter (avionics environment, isotopic neutron sources) 6. Other Si microdosimetric structures (DRAM , FGMOSFET etc) 7. Conclusion and tips for thinking on new Si microdosimeters design

Speaker: Prof. Anatoly Rozenfeld (UOW)

Slides ARDENT_2013_Anatoly_siliconmicrodosimetry.pdf

16:00 Coffee break

16:30 A monolithic silicon telescope for solid state microdosimetry

1. The detection system: features, advantages and drawbacks. 2. Microdosimetry of neutron fields: numerical studies and experimental characterizations. 3. Quality assessment of clinical proton beams: microdosimetric characterization and direct comparison with TEPCs. 4. Microdosimetry of carbon beams: preliminary tests. 5. A silicon microdosimeter integrated into a nanodosimeter.

Speaker: Andrea Pola (Politecnico di Milano)

Slides Pola__A_monolithic_silicon_telescope_for_solid_state_microdosimetry.pdf Pola__A_monolithic_silicon_telescope_for_solid_state_microdosimetry.pptx

20:00 → 23:00 Social Dinner

Friday 18 October

09:00 → 18:00 Training Courses on Experimental Micro- and Nano-dosimetry

09:00 From microdosimetry to nanodosimetry

Radiation-induced damage to living cells or genes is governed, to the greater part, by the pattern of inelastic interactions of ionizing particles in sub-cellular targets (segments of the DNA, nucleosomes, or segments of the chromosome fibre). In consequence, the effectiveness and quality of ionizing radiation should be defined more in terms of quantities which are directly related to the track structure of ionizing radiation than in terms of macroscopic quantities like absorbed dose and linear energy transfer (LET). At the same time, these quantities should be measurable by physical means. To tackle this challenge to radiation metrology, a track-structure based concept of radiation damage has been developed assuming that the initial damage to nanometre-sized volumes like the DNA is mainly due to the number of ionizing processes of single particles within a target volume or in its near neighbourhood. This number of particle interactions (the so-called ionization-cluster size) is measurable in gases using single-ion or single-electron counting techniques, and serves as a measure of the degree of radiation damage; the corresponding cluster-size frequency then serves as a measure of the radiation-induced damage probability. Radiation damage is described, therefore, in terms of particle interaction probabilities in nanometric volumes (nanodosimetry) instead of micrometric volumes (microdosimetry). In this way the traditional description of radiation damage in terms of LET and absorbed dose is exchanged by a probabilistic description of cluster-size formation which characterizes the interaction pattern of ionizing radiation in nanometric volumes and, thus, the particles’ track structure. To check the validity of the track-structure-based concept of radiation quality, experimental radiobiological data are compared with nanodosimetric quantities derived from cluster-size frequencies calculated by Monte Carlo simulations for ionizing particles at different radiation qualities assuming nanometre-sized liquid-water targets as substitutes of short segments of the DNA. This comparison shows a clear relation between track-structure-based nanodosimetric quantities and radiobiological data, which can also be expected if ionization-cluster-size frequencies are measured in gaseous target volumes filled, for instance, with molecular nitrogen or propane at low gas pressure.

Speaker: Prof. Bernd Grosswendt (PTB (retired))

Slides Grosswendt__From_Microdosimetry_to_Nanodosimetry.pdf Grosswendt__From_Microdosimetry_to_Nanodosimetry.pptx

10:00 THE STARTRACK EXPERIMENT - Nanodosimetric STructure of hAdRon TRACKs

GENERALITIES OF TRACK STRUCTURE THE EXPERIMENTAL SET UP - The rational of the experiment - The measuring procedure DATA ACQUISITION AND DATA ANALYSIS - How to handle experimental data RESULTS - Some interesting features of the track structure of light ions - The link to radiobiology

Speaker: Valeria Conte

Slides Conte_nanodosimetric_STructure_of_hAdRon_TRACKs.pdf Conte_nanodosimetric_STructure_of_hAdRon_TRACKs.pptx

11:00 Coffee break

11:30 Microdosimetry with GEM and GEM-PIX

Speaker: Dr Fabrizio Murtas (Istituto Nazionale Fisica Nucleare (IT))

Slides Murtas_Micro_Dosimetry__with_GEM_and_GEMpix.pdf Murtas_Micro_Dosimetry__with_GEM_and_GEMpix.ppt

12:30 Lunch

14:00 Practical training on TEPCs

Speakers: Dr Davide Moro (LNL INFN), Dr Paolo Colautti (LNL INFN)