ICTR-PHE 2016

from Monday, 15 February 2016 (12:00) to Friday, 19 February 2016 (15:40)
Centre International de Conferences de Geneve (CICG)

        : Sessions
    /     : Talks
        : Breaks
15 Feb 2016
16 Feb 2016
17 Feb 2016
18 Feb 2016
19 Feb 2016
AM
08:30
Nuclear Medicine - Thomas Beyer Osman Ratib (until 10:00) ()
08:30 Quantitative Theranostics in Nuclear Medicine - Michael Lassmann   (2)
09:00 Manufacturing and Nuclear Medicine Applications of the Novel Isotope Sn-117m - Nigel Stevenson   (2)
09:15 Contribution of direct and bystander effects to therapeutic efficacy of alpha-RIT using ²¹²Pb-labeled mAbs - Jean-Pierre Pouget   (2)
09:30 64Cu-Labeled Folate Radioconjugate for PET Imaging of Folate Receptor-Positive Tumors - Renata Farkas   (2)
09:45 Radiolabeled Acridine Orange (AO) Derivatives as DNA-Targeted Probes for Auger Therapy - Antonio Paulo   ()
10:00 --- Coffee break ---
10:30
Detectors & Imaging - Denis Dauvergne Alberto Del Guerra (until 14:15) (2)
10:30 Imaging for online control of particle therapy - Thomas Bortfeld   (2)
11:00 First clinical application of a prompt gamma based in vivo proton range verification using a knife-edge slit camera - Christian Richter   (2)
11:30 New Results with Monolithic Scintillators for Time-of-Flight PET - Dennis Schaart   (2)
11:45 Development of a High Resolution Module for PET scanners - Gianluca Stringhini   (2)
12:00 J-PET: a novel TOF-PET scanner based on plastic scintillators - Pawel Moskal   (2)
12:15 Development of a radioguided surgery technique with beta- decays in brain tumor resection - Riccardo Faccini   (2)
12:30 --- Lunch ---
13:30 Range Verification with Ionoacoustics: simulations and measurements at a clinical proton synchro-cyclotron - Sebastian Lehrack   (2)
13:45 Measurement of Acoustic Emissions Generated by a Pulsed Proton Beam from a Hospital-Based Clinical Cyclotron - Kevin Jones   (2)
14:00 Fast Beam Profile Monitors for Microbeam Radiation Therapy - Bjarne Stugu   (2)
08:30
ESTRO lecture - Yolande Lievens (until 09:00) ()
08:30 How emerging trends in basic research & technology will shape clinical research? - Eric Deutsch   ()
09:00
Plenary - Ugo Amaldi Norman Coleman (until 10:00) (2)
09:00 Is Distributed learning the solution for Rapid Learning Health Care? - Philippe Lambin   (2)
09:30 Biological stratification in times of highly conformal radiotherapy - status and perspectives - Michael Baumann   (2)
10:00 --- Coffee and poster viewing ---
11:00
Plenary - Ugo Amaldi Norman Coleman (until 12:00) ()
11:00 Biological issues and their clinical implications in proton therapy - Radhe Mohan   ()
11:30 Single particle detection for spectroscopic CT and tracking in hadron therapy using Medipix chips - Michael Campbell   ()
08:15
GH Fletcher Lecture - James Cox (until 08:50) (2)
08:15 Multimodality Precision Medicine - Søren Bentzen   (2)
08:50
Genomics - Simon Powell (until 10:05) (3)
08:50 The search for genetic predictors of radiotherapy response - Dirk De Ruysscher   (3)
09:15 RSI: A genomic signature of radiosensitivity - Peter A. Johnstone   (3)
09:40 Radiomics in Liquid Biopsies - Frederic Zenhausern   (3)
08:50
Panel discussion - Roberto Orecchia Vikram Bhadrasain (until 10:05) (2)
08:50 Trials in USA - James Cox   (2)
09:15 Trials in Germany - Jürgen Debus   (2)
09:40 Clinical trials for carbon-ion radiotherapy in Japan - Hirohiko Tsujii   (2)
10:05 --- Coffee break ---
10:30
EORTC session - Sofia Rivera Wilfried Budach (until 12:10) (2)
10:30 Radiotherapy quality assurance platform of the EORTC - Damien Weber   (2)
10:52 Radiotherapy quality assurance platform of the EORTC - André Branquinho   (2)
11:02 Synergy of targeted agents and radiotherapy - Sofia Rivera   (2)
11:24 Lessons from translational research in EORTC Glioma trials - Monika Hegi   (2)
11:46 Data from the EORTC Cancer Survivorship Task Force - Conny Vrieling   (2)
10:30
Proffered papers - Detectors and Imaging - Katia Parodi Paul Lecoq (until 11:45) ()
10:30 Study of the radiation produced by therapeutic He, C and O ion beams impinging on a PMMA target - Alessio Sarti   (3)
10:45 Short-lived Positron Emitters in Beam-on PET ImagingDuring Proton Therapy - Tom Buitenhuis   (3)
11:00 DoPET: an in-treatment monitoring system for particle therapy - Valeria Rosso   (3)
11:15 Commissioning of a Compton camera for ion beam range verification via prompt gamma detection using low-energy and clinical particle beams - Saad Aldawood   (3)
11:30 Prompt Gamma-ray Timing experiment during different modalities of proton beam delivery - Thomas Kormoll   (3)
10:30
Proffered papers - Radiobiology - Mechthild Krause Ulli Köster (until 12:00) (4)
10:30 The effect of fractionated administration of thalidomide at γ-ray irradiation on tumor response and lung metastasis - Shin-ichiro Masunaga   (4)
10:45 Predictive Biomarkers for Improving Radiation Therapy - Pataje Prasanna   (4)
11:00 Targeted Radionuclide Therapy with 161Tb: Investigation of Anti-Tumor Effects and Undesired Side Effects - Cristina Müller   (4)
11:15 The relationship between absorbed dose and DNA Damage in Lymphocytes after radionuclide therapy - Uta Eberlein   (4)
11:30 Modeling the effect of symmetrical division of cancer stem cells on tumour response to radiation - Loredana Marcu   (4)
11:45 A dose response analysis of the patients treated with Boron Neutron Capture Therapy (BNCT) in Finland in 1999 to 2011 - Hanna Koivunoro   (4)
08:30
Biomolecular mechanisms driving modulation of tumor cell sensitivity - Zvi Fuks Martin Pruschy (until 09:45) ()
08:30 Genetic and pharmacological inhibition of autophagy after irradiation - Kasper Rouschop   (2)
08:55 Oncometabolite lactate promotes tumour growth - Pierre Sonveaux   (2)
09:20 Determining cell radiosensitivity using assays in ex vivo irradiated tumour specimens - Daniel Zips   (2)
08:30
MEDICIS - PROMED program - Osman Ratib Thierry Stora (until 09:45) (3)
08:30 MEDICIS-PROMED : a ITN Marie-Curie network on nuclear medicine and 11C-based hadron-therapy - Johanna Pitters   (3)
08:40 MEDICIS-PROMED: MEDICIS-Produced Radioisotope Beams for Medicine an Innovative Training Network - John Prior   (3)
09:05 Recurrent glioblastoma multiforme – targeted alpha therapy with 213Bi-DOTA-Substance P - Frank Bruchertseifer   (3)
09:25 Medical isotope production at TRIUMF and future collaboration with MEDICIS-PROMED - Yann Seimbille   (3)
08:30
Oral poster presentation- Detectors and Imaging - Michael Campbell Mike Waligórski (until 09:40) ()
08:30 Comparison of Arterial Input Functions by Magnitude and Phase Signal Measurement in DCE MRI of brain cancer patients - Catherine Coolens   (4)
08:40 Fast calibration of the range of Carbon ionswith in-beam PET of Boron-8 nuclei - Caterina Cuccagna   (4)
08:50 An online beam monitor detector for medical applications of ion beams - Saverio Braccini   (4)
09:00 The GEMPIX detector for energy deposition measurements in Hadrontherapy - Fabrizio Murtas   (4)
09:10 GPU based iterative CBCT for prospective motion compensated algorithm for radiation therapy - Ander Biguri   (4)
09:20 Measurements and simulations of in-phantom neutron dose from a proton pencil beam - Kristian Ytre-Hauge   (4)
09:30 CHIC – A Multi-scale Modelling Platform for in-silico Oncology - Daniel Abler   (4)
09:45 --- Coffee break ---
10:15
Oral poster presentation - Miscellaneous - Jan Alsner Alessandra Bolsi (until 11:25) (4)
10:15 Clinical validation of the M5L lung Computer-Assisted Detection system - Piergiorgio Cerello   (4)
10:25 Tuning of a 4D ML reconstruction strategy for treatment verification in ion beam radiotherapy - Katia Parodi   (4)
10:35 Differential cross sections measurements for hadrontherapy: 50 MeV/n 12C reactions on H, C, Al, O and natTi targets - Clovis Divay   (4)
10:45 Metal implanted multi-functional nanovectors for targeted radiotherapy and diagnostics of cancer - Asénath Etilé   (4)
10:55 The Malthus Project - updated predictions of national radiotherapy demand to 2030 - Thomas Mee   (4)
11:05 The use of radiobiological TCP and NTCP models to validate the dose calculation algorithm and readjust the prescribed dose - Jacques Balosso   (4)
11:15 Status of the CaLIPSO High-Resolution PET Project - Xavier Mancardi   (4)
10:15
Oral poster presentation- Clinics - Esther Troost (until 11:25) ()
10:15 The use of 149Tb and 152Tb in preclinical investigations: an update on its mass separation and subsequent application for imaging and therapy - Nicholas van der Meulen   (3)
10:25 Design of electronic data processing system for radiotherapy study: lessons learned from VoxTox - Marina Romanchikova   (3)
10:35 Assessment tool to quantify and visualize treatment plan robustness regarding patient setup - Michael Fix   (3)
10:45 A Hypercellular Component of Glioblastoma Identified by High b-value Diffusion Weighted Imaging - Yue Cao   (3)
10:55 Treatment of moving targets with active scanning carbon ion beams - Piero Fossati   (3)
11:05 Distributed learning: predictive models based on data from multiple hospitals without data leaving the hospital - Arthur Jochems   (3)
11:15 A clinical protocol for Simultaneous Integrated Boost for proton treatment of Head and Neck carcinoma - Francesca Belosi   (3)
10:15
Panel discussion - Manjit Dosanjh Jens Overgaard (until 11:30) (2)
10:15 Conceptual Design report for OpenMED - Ghislain Roy   (2)
10:40 OPENMED: Topics, Issues and Wishes - Mike Waligórski   (2)
11:05 Role of the CERN International Strategy Committee in the LEIR initiative: Biology - Philippe Lambin   (2)
11:30 --- Poster viewing ---
PM
13:00 Welcome address and opening - Jacques Bernier (GSMN) Manjit Dosanjh (CERN) Eckhard Elsen (CERN)   (2)
13:30
Radiobiology - Marco Durante Kevin Prise (until 16:45) ()
13:30 A comprehensive omics approach for development of prognostic or predictive biomarkers in squamous cell carcinoma of the head and neck treated with radiation - Michael Story   (2)
14:00 What are the Dominant Radiobiological Mechanisms at Play in Stereotactic Radiotherapy? - David Brenner   ()
14:30 The symbiosis of science of radiation biology with immunology: Impact on basic and translational research - Ahmed Mansoor   (2)
14:45 The relevance of DNA damage clustering on the nanometer and micrometer scale for the quantitative prediction of radiation effects - Michael Scholz   ()
15:00 Correlation of Particle Traversals with Clonogenic Survival Using Cell-Fluorescent Ion Track Hybrid Detector - Ivana Dokic   ()
15:15 Radiation induced DNA damage in human uveal melanoma cells - Katarzyna Jasińska   ()
15:30 --- Coffee break ---
16:00 Quantum dots imaging tests on SPAD for nanodosimetric applications - Alberto Quaranta   (2)
16:15 Disruption of telomere equilibrium sensitises human cancer cells to DNA repair inhibition and radiation - Prakash Hande   (2)
16:30 Investigating the impact of a variable RBE on proton dose fractionation across an actively scanned spread-out Bragg peak - Kevin Prise   (2)
16:45
Nuclear Medicine - Thomas Beyer Osman Ratib (until 18:00) ()
16:45 Molecular imaging for theranostics - Wim Oyen   (2)
17:15 Early variation of FDG-PET radiomics features in NSCLC is related to overall survival - the “delta radiomics” concept - Ralph Leijenaar   (2)
17:30 How to produce scandium-44 and scandium-43 efficiently? - Charlotte Duchemin Katharina Domnanich Jerzy Jastrzębski   (2)
14:15
New Technologies - Hans-Peter Meinzer Wolfgang Enghardt (until 15:45) ()
14:15 MRI for external beam radiotherapy guidance - Jan Lagendijk   (2)
14:45 MRI Guided Proton Therapy: pencil beam scanning in an MRI fringe field - Brad Oborn   (2)
15:00 Nanoparticle Enhanced MRI-Guided Radiation Therapy: Final proof of concept before phase I trial - Shady Kotb   (2)
15:15 Hadron minibeam radiation therapy: feasibility study at the Heidelberg IonBeam Therapy Center (HIT) - Immaculada Martínez-Rovira   (2)
15:30 Evaluation of long-term effects of synchrotron-generated microbeams on rat hippocampal neurogenesis - Alberto Bravin   (2)
15:45 --- Coffee Break ---
16:15
New Technologies - Hans-Peter Meinzer Wolfgang Enghardt (until 17:30) ()
16:15 Big Data in Radiation Oncology: data gathering, data processing, algorithms and clinical impact - Klaus Maier-Hein   ()
16:45 Expert knowledge and data-driven Bayesian Networks to predict post-RT dyspnea and 2-year survival - Timo Deist   (2)
17:00 Dosimetry of ultra high dose rate irradiation for studies on the biological effect induced in normal brain and GBM - Kristoffer Petersson   (2)
17:15 Geant4 coupled with Comsol heat transfer simulations to determine correction factors of a novel micro-calorimeter - Kamran Fathi   ()
18:30 Public talk - Sound for Health - Domenico Vicinanza - Domenico Vicinanza   (2)
12:00 --- Lunch & Exhibitor presentations ---
13:00
Novel approaches in imaging - Philippe Lambin (until 14:15) (2)
13:00 New hypoxia probe development based on mass spectrometry - Brad Wouters   (2)
13:25 The role of functional imaging for radiation oncology – The whole translational chain from animals to clinics - Esther Troost   (2)
13:50 Is dual energy CT the next standard imaging modality for radiotherapy? - Wouter van Elmpt   (2)
13:00
Particle therapy (I) - Hirohiko Tsujii Jürgen Debus (until 14:15) (3)
13:00 Proton Radiation Therapy: Current Status at Massachusetts General Hospital - Thomas DeLaney   (3)
13:25 MedAustron - status and vision - Eugen Hug   (3)
13:50 Particle therapy centre in Shanghai - Zhen Zhang   (3)
13:00
Proffered papers- clinical - Carlo Greco (until 14:15) (4)
13:00 Urethra-sparing SBRT for prostate cancer: dosimetric optimization with VMAT vs. IMRT and the learning curve effect - Thomas Zilli   (4)
13:15 A novel method to predict a priori the toxicity reduction of a prostate-rectum spacer: Virtual Rectum Spacer - Ben Vanneste   (4)
13:30 Local Tumor Flare Following Radiosurgery and Ipilimumab (Ipi) for Melanoma Brain Metastases: Increased Immune Response? - Caroline Chung   (4)
13:45 Response-based Bayesian Network Approaches for Adaptive Radiotherapy of Non-Small Cell Lung Cancer (NSCLC) - Randall Ten Haken   (4)
14:00 Further Development of Spinal Tissue Radiotherapy Re-treatment Modelling, with inclusion of Hadrontherapy - Bleddyn Jones   (4)
14:15
Oral poster presentation- Physics/Biology - Dag-Rune Olsen (until 15:45) (4)
14:15 Proton Minibeam Radiation Therapy (pMBRT): implementation at a clinical center - Cécile Peucelle   (4)
14:25 Investigation of the use of inhomogeneous fractional dose distributions in IMPT to improve the therapeutic index - Lorenzo Manganaro   (4)
14:35 Accuracy of portal dosimetry in hybrid IMRT and VMAT treatment of the prostate - James Bedford   (4)
14:45 ODSH as a countermeasure for radiation-induced thrombocytopenia: Dosimetric studies - Stephen Avery   (4)
14:55 Measurements of Reactive Oxygen Species production induced by Gold Nanoparticles in Radiotherapy protoco - Piergiorgio Cerello   (4)
15:05 NanoxTM: A new multiscale theoretical framework to predict cell survival in the context of particle therapy - Micaela Cunha   (4)
15:15 Simulation of cell survival for proton broad and minibeam radiotherapy with hexagonal and square minibeam alignment - Matthias Sammer   (4)
15:25 Microbeam Radiation Therapy (MRT): achievements and future perspectives - Elke Bräuer-Krisch   (4)
15:35 The role of adipose stromal cells for reversal of radiation fibrosis - Fei-Fei Liu   (4)
14:15
Panel discussion - Hans Langendijk Søren Bentzen (until 15:55) (3)
14:15 Current and future strategies developed at Paul Scherrer Institute - Alessandra Bolsi   (3)
14:40 Optimizing prostate cancer irradiation: from technology to fractionation - Raymond Miralbell   (3)
15:05 Technological advancement in radiation oncology - Hak Choy   (3)
15:30 Main challenges in adaptive radiotherapy - Jan-Jakob Sonke   (3)
14:15
Panel discussion - Karin Haustermans (until 15:55) (2)
14:15 The Biology of Single Dose Radiotherapy - Zvi Fuks   (2)
14:40 Are there common signaling pathways among highly radioresistant tumors? The examples of high grade gliomas and sarcomas - Elizabeth Moyal   (2)
15:05 HIF-related therapeutic windows - Amato Giaccia   (2)
15:30 Vascular disrupting agents: a new avenue of research - Michael Horsman   (2)
15:55 --- Coffee break ---
16:30
Novel strategies to overcome cancer (I): Immunology-based attacks - Marce Verheij (until 17:45) (2)
16:30 Oncolytic viruses - Kevin Harrington   (2)
16:55 Synergy of radiotherapy and cancer vaccines in HPV-positive tumors - Eric Deutsch   (2)
17:20 Radiotherapy and the immunocytokine L19-IL2: a perfect match for an abscopal effect with long-lasting memory - Ludwig Dubois   (2)
16:30
Novel strategies to overcome cancer (II): Enhancing the ratio between tumor cell killing and normal tissue protection - Raymond Miralbell (until 17:45) (3)
16:30 Pelvic tumor irradiation: new tools to reduce toxicity: from technology to drugs - Karin Haustermans   (3)
16:55 Towards a new type of irradiation - Jean Bourhis   (3)
17:20 Treatment outcome in patients treated with single-dose irradiation (SDRT) for oligometastatic disease - Carlo Greco   (2)
16:30
Proffered papers - Emerging technologies - Marco Silari Vincenzo Patera (until 17:45) (4)
16:30 Geometrical interpretation of TOF PET raw data in commercial PET-CT scanner for SNR optimization - Chiara Gianoli   (4)
16:45 Characterization and test beam results of a LaBr3 Compton Telescope for treatment monitoring - Gabriela Llosá   (4)
17:00 Small Large Momentum Acceptance Gantries for Proton and Carbon Cancer Therapy - Dejan Trbojevic   (4)
17:15 X-Ray Phase contrast micro-imaging in neuroscience - Giacomo Barbone   (4)
17:30 Water based 3D optical dose imaging for particle therapy - Oksana Kavatsyuk   (4)
19:00 --- Gala dinner with Keynote by Vytenis Andriukaitis, EC Health Commissioner ---
12:00
Lunch & Start-up presentations (until 13:00) ()
13:00
European School of Oncology - E. van der Schueren Award - Fedro Peccatori (until 13:30) (2)
13:00 Tackling Phenotypic Diversity to Increase Cures - Brad Wouters   (2)
13:30
Novel strategies to overcome cancer: Tumor cell radiosensitivity modulation - Jacques Bernier Jean Bourhis (until 14:45) (3)
13:30 Novel anti-tumor agents targeting cell membrane - Marcel Verheij   (3)
13:55 Stroma mediated wound healing signals and cell response to radiation - Marie-Catherine Vozenin   (3)
14:20 Targeting tumor heterogeneity - Gerben Borst   (3)
13:30
Proffered papers - Physics - Thomas Bortfeld (until 14:45) ()
13:30 Towards analytic dose calculation for MR guided particle beam therapy - Hermann Fuchs   (4)
13:45 Experimental dosimetric comparisons of protons, helium, carbon and oxygen ion beams - Thomas Tessonnier   (4)
14:00 Implementation of an analytical solution to lateral dose prediction in a proton therapy treatment planning system - Valentina Elettra Bellinzona   (4)
14:15 Utilizing CBCT data for dose calculation in adaptive IMPT - Christopher Kurz   (4)
14:30 Can we replace high quality simulation CT by simple kV-cone-beam CT images to extract an externally validated radiomics signature? - Janita van Timmeren   (4)
13:30
Revisiting RBE - Jens Overgaard (until 14:45) (2)
13:30 In-vitro RBE - Marco Durante   (2)
13:55 Carbon ion radiotherapy: do we understand each other? How to compare differentt RBE-weighted dose systems in the clinical setting - Piero Fossati   (2)
14:20 Physics and RBE - Tony Lomax   (2)
14:45 --- Coffee and poster viewing ---
16:15
Emerging challenges in combating cancer - Vincent Grégoire (until 17:30) (3)
16:15 Emerging challenges in combating cancer - Norman Coleman   (3)
16:40 Targeted Treatment for the Non- Small Cell Lung Cancer - Ritsuko Komaki   (3)
17:05 Magnetic resonance temperature imaging in clinical hyperthermia: past experience and prospects - Peter Wust   (3)
16:15
Particle therapy (II) - Jacques Balosso Damien Weber (until 17:30) (2)
16:15 Current status of particle therapy at CNAO - Roberto Orecchia   (2)
16:40 Integration of economic data in clinical trials - Yolande Lievens   (2)
17:05 Current status of particle therapy in The Netherlands - Hans Langendijk   (2)
16:15
Proffered papers -Biology - Amato Giaccia Michael Horsman (until 17:30) (4)
16:15 Radiation treatment monitoring using multifunctional imaging in prostate tumour xenografts - Natalia Arteaga-Marrero   (4)
16:30 Robustness and reliability of PET-based identification and quantification of tumor hypoxia, using simple static or more complex scan acquisitions - Morten Busk   (4)
16:45 Variable RBE in proton therapy: comparison of model predictions and their impact on clinical-like cranial lesions - Julia Bauer   (4)
17:00 Inhibiting the actions of cathepsin L effects both tumour initiation and metastasis formation - Thomas Wittenborn   (4)
17:15 Plerixafor Improves Local Control and Reduces Metastases in Cervical Cancer Treated with Radiotherapy and Chemotherapy - Michael Milosevic   (4)
12:00 --- Lunch ---
12:45
Panel discussion - Daniel Zips (until 14:00) (2)
12:45 Multimodal approach to assess tumour vasculature and potential treatment effect - Dag Rune Olsen   (2)
13:10 Hypoxia-guided adaptive radiation dose escalation in head and neck carcinoma - Vincent Gregoire   (2)
13:35 Microtubule-stabilizing agents with inhibitors of angiogenesis to overcome resistance - Martin Pruschy   (2)
12:45
Preclinical models - Richard Kolesnick (until 14:00) (3)
12:45 Orthotopic tumor models for glioma and NSCLC - Jan Theys   (3)
13:10 High Performance Preclinical Irradiation Through Optimized Dual Focal Spot Dose Painting and Online Virtual Isocenter Radiation Field Targeting - David Jaffray   (3)
13:35 Studying radiotherapy resistance of BRCA1-mutated mammary tumors - Sven Rottenberg   (2)
12:45
Winning posters - Jacques Bernier Manjit Dosanjh (until 14:00) ()
14:00
Modulating response to radiation - Elizabeth Moyal (until 15:15) (3)
14:00 Balanced checkpoint activation: genomic stability and cell response to radiation - Simon Powell   (3)
14:25 Macrophage reprogramming for anticancer therapy - Michele De Palma   (3)
14:50 Focal adhesion signaling and therapy resistance in cancer - Anne Vehlow   (3)
14:00
Research seminar:Overcoming cancer radioresistance - Brad Wouters (until 15:15) ()
14:00 Factors of radioresistance in prostate cancer - Mechthild Krause   (2)
14:25 Targeting NOTCH pathway in Glioblastoma - Marc Vooijs   (2)
14:50 Human Sphingolipid Biomarkers of Single Dose Radiotherapy: A Clinical trial - Richard Kolesnick   (2)
15:15
Concluding remarks - Jacques Bernier Manjit Dosanjh (until 15:40) (2)